Whole-genome sequence analysis of Zika virus, amplified from urine of traveler from the Philippines

Zika virus (ZIKV) (genus Flavivirus , family Flaviviridae ) is an emerging pathogen associated with microcephaly and Guillain-Barré syndrome. The rapid spread of ZIKV disease in over 60 countries and the large numbers of travel-associated cases have caused worldwide concern. Thus, intensified survei...

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Bibliographic Details
Published in:Virus genes 2017-12, Vol.53 (6), p.918-921
Main Authors: Gu, Se Hun, Song, Dong Hyun, Lee, Daesang, Jang, Jeyoun, Kim, Min Young, Jung, Jaehun, Woo, Koung In, Kim, Mirang, Seog, Woong, Oh, Hong Sang, Choi, Byung Seop, Ahn, Jong-Seong, Park, Quehn, Jeong, Seong Tae
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Disease control
Flavivirus
Genomes
Guillain-Barre syndrome
Humans
Immigrants
Medical Microbiology
Microencephaly
Nucleotide sequence
Philippines
Phylogeny
Plant Sciences
Republic of Korea
Travel
Urine
Virology
Whole Genome Sequencing - methods
Zika virus
Zika Virus - genetics
Zika Virus Infection - virology
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Summary:Zika virus (ZIKV) (genus Flavivirus , family Flaviviridae ) is an emerging pathogen associated with microcephaly and Guillain-Barré syndrome. The rapid spread of ZIKV disease in over 60 countries and the large numbers of travel-associated cases have caused worldwide concern. Thus, intensified surveillance of cases among immigrants and tourists from ZIKV-endemic areas is important for disease control and prevention. In this study, using Next Generation Sequencing, we reported the first whole-genome sequence of ZIKV strain AFMC-U, amplified from the urine of a traveler returning to Korea from the Philippines. Phylogenetic analysis showed geographic-specific clustering. Our results underscore the importance of examining urine in the diagnosis of ZIKV infection.
ISSN:0920-8569
1572-994X
DOI:10.1007/s11262-017-1500-9