Renal toxicity and chemotherapy in children with cancer

The clinical use of antineoplastic drugs can be limited by different drug‐induced toxicities. Of these, renal dysfunction may be one of the most troublesome in that it can be cumulative and in general is only partially reversible with the discontinuation of the treatment. Renal toxicity may be manif...

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Bibliographic Details
Published in:British journal of clinical pharmacology 2017-12, Vol.83 (12), p.2605-2614
Main Authors: Ruggiero, Antonio, Ferrara, Pietro, Attinà, Giorgio, Rizzo, Daniela, Riccardi, Riccardo
Format: Article
Language:English
Subjects:
Age of Onset
Antineoplastic Agents - adverse effects
chemotherapy
Child
Child, Preschool
children
Cisplatin - adverse effects
Humans
Ifosfamide - adverse effects
Incidence
Infant
Kidney - drug effects
Kidney - physiopathology
Kidney Diseases - chemically induced
Kidney Diseases - diagnosis
Kidney Diseases - epidemiology
Kidney Diseases - physiopathology
Kidney Function Tests
Neoplasms - drug therapy
nephrotoxicity
Review
Reviews
Risk Factors
Treatment Outcome
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Summary:The clinical use of antineoplastic drugs can be limited by different drug‐induced toxicities. Of these, renal dysfunction may be one of the most troublesome in that it can be cumulative and in general is only partially reversible with the discontinuation of the treatment. Renal toxicity may be manifested as a reduction of the glomerular filtration rate, electrolyte imbalances, or acute renal failure. Careful assessment of renal function has to be performed taking into account that the impairment of renal function is initially silent and only later may be clinically dramatic. When clinically indicated, the reduction or, in cases of severe nephrotoxicity, the suspension of chemotherapy should be considered to avoid the progressive deterioration of the compromised glomerular and/or tubular function.
ISSN:0306-5251
1365-2125
DOI:10.1111/bcp.13388