Endothelial cell-cell adhesion and signaling

Endothelial cells line blood vessels and provide a dynamic interface between the blood and tissues. They remodel to allow leukocytes, fluid and small molecules to enter tissues during inflammation and infections. Here we compare the signaling networks that contribute to endothelial permeability and...

Full description

Saved in:
Bibliographic Details
Published in:Experimental cell research 2017-09, Vol.358 (1), p.31-38
Main Authors: Cerutti, Camilla, Ridley, Anne J.
Format: Article
Language:English
Subjects:
Actin cytoskeleton
Actins - metabolism
Adherens junctions
Adherens Junctions - metabolism
Animals
Cell Adhesion - physiology
Cell signaling
Endothelial cells
Endothelial Cells - metabolism
GTPases
Humans
Leukocytes - cytology
Rap GTPases
Rho
Signal Transduction - physiology
Tight junctions
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Endothelial cells line blood vessels and provide a dynamic interface between the blood and tissues. They remodel to allow leukocytes, fluid and small molecules to enter tissues during inflammation and infections. Here we compare the signaling networks that contribute to endothelial permeability and leukocyte transendothelial migration, focusing particularly on signals mediated by small GTPases that regulate cell adhesion and the actin cytoskeleton. Rho and Rap GTPase signaling is important for both processes, but they differ in that signals are activated locally under leukocytes, whereas endothelial permeability is a wider event that affects the whole cell. Some molecules play a unique role in one of the two processes, and could therefore be targeted to selectively alter either endothelial permeability or leukocyte transendothelial migration.
ISSN:0014-4827
1090-2422
DOI:10.1016/j.yexcr.2017.06.003