Effects of Electrostatic Field on Osteoblast Cells for Bone Regeneration Applications

Many external stimulations have been shown to promote bone regeneration. The effects of an alternating current (AC) electrostatic field, one of external stimulations, generated from a device with high voltage and low current output on human osteoblastic cell line have been investigated in this study...

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Bibliographic Details
Published in:BioMed research international 2017-01, Vol.2017 (2017), p.1-9
Main Authors: Su, Chen-Ying, Fang, Hsu-Wei, Fang, Tzan
Format: Article
Language:English
Subjects:
Alkaline phosphatase
Alternating current
Aluminum
Biocompatibility
Bone growth
Bone marrow
Bone regeneration
Bone Regeneration - radiation effects
Cell culture
Cell Differentiation - radiation effects
Cell division
Cell Division - radiation effects
Cell Line
Chemical compounds
Collagen
Electric fields
Electromagnetism
Electrostatic properties
Experiments
Gene expression
Growth factors
High voltage
Humans
Influence
Magnetic Field Therapy
Osteoblastogenesis
Osteoblasts
Osteoblasts - metabolism
Osteoblasts - radiation effects
Osteocalcin
Osteocalcin - metabolism
Regeneration
Regeneration (physiology)
Stainless steel
Static Electricity
Stem cells
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Summary:Many external stimulations have been shown to promote bone regeneration. The effects of an alternating current (AC) electrostatic field, one of external stimulations, generated from a device with high voltage and low current output on human osteoblastic cell line have been investigated in this study. We investigated how human osteoblasts responded to an AC electrostatic field, and the output parameters were set as 1 kV and 160 μA. Our results showed that, under such condition, the AC electrostatic field had a downregulation effect on the production ability of alkaline phosphatase and type 1 collagen expression. However, the expression of osteocalcin gene was elevated on the end of EFID treatment suggesting that AC electrostatic field might be a potential stimulation for accelerating the differentiation of osteoblastic cells.
ISSN:2314-6133
2314-6141
DOI:10.1155/2017/7124817