Effects of Electrostatic Field on Osteoblast Cells for Bone Regeneration Applications

Many external stimulations have been shown to promote bone regeneration. The effects of an alternating current (AC) electrostatic field, one of external stimulations, generated from a device with high voltage and low current output on human osteoblastic cell line have been investigated in this study...

Full description

Saved in:
Bibliographic Details
Published in:BioMed research international 2017-01, Vol.2017 (2017), p.1-9
Main Authors: Su, Chen-Ying, Fang, Hsu-Wei, Fang, Tzan
Format: Article
Language:English
Subjects:
Alkaline phosphatase
Alternating current
Aluminum
Biocompatibility
Bone growth
Bone marrow
Bone regeneration
Bone Regeneration - radiation effects
Cell culture
Cell Differentiation - radiation effects
Cell division
Cell Division - radiation effects
Cell Line
Chemical compounds
Collagen
Electric fields
Electromagnetism
Electrostatic properties
Experiments
Gene expression
Growth factors
High voltage
Humans
Influence
Magnetic Field Therapy
Osteoblastogenesis
Osteoblasts
Osteoblasts - metabolism
Osteoblasts - radiation effects
Osteocalcin
Osteocalcin - metabolism
Regeneration
Regeneration (physiology)
Stainless steel
Static Electricity
Stem cells
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c499t-25642b4d3ee8b7dc7c54eafc7637ff332e5ee5768f5a429177fb4751c13296f13
cites cdi_FETCH-LOGICAL-c499t-25642b4d3ee8b7dc7c54eafc7637ff332e5ee5768f5a429177fb4751c13296f13
container_end_page 9
container_issue 2017
container_start_page 1
container_title BioMed research international
container_volume 2017
creator Su, Chen-Ying
Fang, Hsu-Wei
Fang, Tzan
description Many external stimulations have been shown to promote bone regeneration. The effects of an alternating current (AC) electrostatic field, one of external stimulations, generated from a device with high voltage and low current output on human osteoblastic cell line have been investigated in this study. We investigated how human osteoblasts responded to an AC electrostatic field, and the output parameters were set as 1 kV and 160 μA. Our results showed that, under such condition, the AC electrostatic field had a downregulation effect on the production ability of alkaline phosphatase and type 1 collagen expression. However, the expression of osteocalcin gene was elevated on the end of EFID treatment suggesting that AC electrostatic field might be a potential stimulation for accelerating the differentiation of osteoblastic cells.
doi_str_mv 10.1155/2017/7124817
format article
fullrecord <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5702948</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A557302597</galeid><sourcerecordid>A557302597</sourcerecordid><originalsourceid>FETCH-LOGICAL-c499t-25642b4d3ee8b7dc7c54eafc7637ff332e5ee5768f5a429177fb4751c13296f13</originalsourceid><addsrcrecordid>eNqNkc1rVDEUxYMottTuXMsDN4Idm5vvbIRxmKpQKIhdh7y8m2nKm5fx5Y3if2-mM07VldnkQH6cm3MPIS-BvgOQ8pJR0JcamDCgn5BTxkHMFAh4etScn5DzUu5pPQYUteo5OWGWSWuNPCW3yxgxTKXJsVn2VY25TH5KoblK2HdNHpqbMmFue1-mZoF9X5qYx-ZDHrD5gisccKx4xeabTZ_Cgy4vyLPo-4Lnh_uM3F4tvy4-za5vPn5ezK9nQVg7zZhUgrWi44im1V3QQQr0MWjFdYycM5SIUisTpRfMgtaxFVpCAM6sisDPyPu972bbrrELOEyj791mTGs__nTZJ_f3y5Du3Cp_d1JTZoWpBm8OBmP-tsUyuXUqoab0A-ZtcWB1HSsp5xV9_Q96n7fjUONVSlkqgRn1SK18jy4NMde5YWfq5lJqTuvidaUu9lSo6y4jxuOXgbpdsW5XrDsUW_FXf8Y8wr9rrMDbPXCXhs7_SP9ph5XB6B9p4IYbyn8B_f2zOQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1969051286</pqid></control><display><type>article</type><title>Effects of Electrostatic Field on Osteoblast Cells for Bone Regeneration Applications</title><source>Publicly Available Content (ProQuest)</source><source>Wiley Open Access</source><creator>Su, Chen-Ying ; Fang, Hsu-Wei ; Fang, Tzan</creator><contributor>Wang, Liping</contributor><creatorcontrib>Su, Chen-Ying ; Fang, Hsu-Wei ; Fang, Tzan ; Wang, Liping</creatorcontrib><description>Many external stimulations have been shown to promote bone regeneration. The effects of an alternating current (AC) electrostatic field, one of external stimulations, generated from a device with high voltage and low current output on human osteoblastic cell line have been investigated in this study. We investigated how human osteoblasts responded to an AC electrostatic field, and the output parameters were set as 1 kV and 160 μA. Our results showed that, under such condition, the AC electrostatic field had a downregulation effect on the production ability of alkaline phosphatase and type 1 collagen expression. However, the expression of osteocalcin gene was elevated on the end of EFID treatment suggesting that AC electrostatic field might be a potential stimulation for accelerating the differentiation of osteoblastic cells.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2017/7124817</identifier><identifier>PMID: 29259985</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Alkaline phosphatase ; Alternating current ; Aluminum ; Biocompatibility ; Bone growth ; Bone marrow ; Bone regeneration ; Bone Regeneration - radiation effects ; Cell culture ; Cell Differentiation - radiation effects ; Cell division ; Cell Division - radiation effects ; Cell Line ; Chemical compounds ; Collagen ; Electric fields ; Electromagnetism ; Electrostatic properties ; Experiments ; Gene expression ; Growth factors ; High voltage ; Humans ; Influence ; Magnetic Field Therapy ; Osteoblastogenesis ; Osteoblasts ; Osteoblasts - metabolism ; Osteoblasts - radiation effects ; Osteocalcin ; Osteocalcin - metabolism ; Regeneration ; Regeneration (physiology) ; Stainless steel ; Static Electricity ; Stem cells</subject><ispartof>BioMed research international, 2017-01, Vol.2017 (2017), p.1-9</ispartof><rights>Copyright © 2017 Chen-Ying Su et al.</rights><rights>COPYRIGHT 2017 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2017 Chen-Ying Su et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2017 Chen-Ying Su et al. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-25642b4d3ee8b7dc7c54eafc7637ff332e5ee5768f5a429177fb4751c13296f13</citedby><cites>FETCH-LOGICAL-c499t-25642b4d3ee8b7dc7c54eafc7637ff332e5ee5768f5a429177fb4751c13296f13</cites><orcidid>0000-0001-8931-8434 ; 0000-0001-7865-9145</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1969051286/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1969051286?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,25731,27901,27902,36989,36990,44566,74869</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29259985$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Wang, Liping</contributor><creatorcontrib>Su, Chen-Ying</creatorcontrib><creatorcontrib>Fang, Hsu-Wei</creatorcontrib><creatorcontrib>Fang, Tzan</creatorcontrib><title>Effects of Electrostatic Field on Osteoblast Cells for Bone Regeneration Applications</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Many external stimulations have been shown to promote bone regeneration. The effects of an alternating current (AC) electrostatic field, one of external stimulations, generated from a device with high voltage and low current output on human osteoblastic cell line have been investigated in this study. We investigated how human osteoblasts responded to an AC electrostatic field, and the output parameters were set as 1 kV and 160 μA. Our results showed that, under such condition, the AC electrostatic field had a downregulation effect on the production ability of alkaline phosphatase and type 1 collagen expression. However, the expression of osteocalcin gene was elevated on the end of EFID treatment suggesting that AC electrostatic field might be a potential stimulation for accelerating the differentiation of osteoblastic cells.</description><subject>Alkaline phosphatase</subject><subject>Alternating current</subject><subject>Aluminum</subject><subject>Biocompatibility</subject><subject>Bone growth</subject><subject>Bone marrow</subject><subject>Bone regeneration</subject><subject>Bone Regeneration - radiation effects</subject><subject>Cell culture</subject><subject>Cell Differentiation - radiation effects</subject><subject>Cell division</subject><subject>Cell Division - radiation effects</subject><subject>Cell Line</subject><subject>Chemical compounds</subject><subject>Collagen</subject><subject>Electric fields</subject><subject>Electromagnetism</subject><subject>Electrostatic properties</subject><subject>Experiments</subject><subject>Gene expression</subject><subject>Growth factors</subject><subject>High voltage</subject><subject>Humans</subject><subject>Influence</subject><subject>Magnetic Field Therapy</subject><subject>Osteoblastogenesis</subject><subject>Osteoblasts</subject><subject>Osteoblasts - metabolism</subject><subject>Osteoblasts - radiation effects</subject><subject>Osteocalcin</subject><subject>Osteocalcin - metabolism</subject><subject>Regeneration</subject><subject>Regeneration (physiology)</subject><subject>Stainless steel</subject><subject>Static Electricity</subject><subject>Stem cells</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNqNkc1rVDEUxYMottTuXMsDN4Idm5vvbIRxmKpQKIhdh7y8m2nKm5fx5Y3if2-mM07VldnkQH6cm3MPIS-BvgOQ8pJR0JcamDCgn5BTxkHMFAh4etScn5DzUu5pPQYUteo5OWGWSWuNPCW3yxgxTKXJsVn2VY25TH5KoblK2HdNHpqbMmFue1-mZoF9X5qYx-ZDHrD5gisccKx4xeabTZ_Cgy4vyLPo-4Lnh_uM3F4tvy4-za5vPn5ezK9nQVg7zZhUgrWi44im1V3QQQr0MWjFdYycM5SIUisTpRfMgtaxFVpCAM6sisDPyPu972bbrrELOEyj791mTGs__nTZJ_f3y5Du3Cp_d1JTZoWpBm8OBmP-tsUyuXUqoab0A-ZtcWB1HSsp5xV9_Q96n7fjUONVSlkqgRn1SK18jy4NMde5YWfq5lJqTuvidaUu9lSo6y4jxuOXgbpdsW5XrDsUW_FXf8Y8wr9rrMDbPXCXhs7_SP9ph5XB6B9p4IYbyn8B_f2zOQ</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Su, Chen-Ying</creator><creator>Fang, Hsu-Wei</creator><creator>Fang, Tzan</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley &amp; Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8931-8434</orcidid><orcidid>https://orcid.org/0000-0001-7865-9145</orcidid></search><sort><creationdate>20170101</creationdate><title>Effects of Electrostatic Field on Osteoblast Cells for Bone Regeneration Applications</title><author>Su, Chen-Ying ; Fang, Hsu-Wei ; Fang, Tzan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-25642b4d3ee8b7dc7c54eafc7637ff332e5ee5768f5a429177fb4751c13296f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Alkaline phosphatase</topic><topic>Alternating current</topic><topic>Aluminum</topic><topic>Biocompatibility</topic><topic>Bone growth</topic><topic>Bone marrow</topic><topic>Bone regeneration</topic><topic>Bone Regeneration - radiation effects</topic><topic>Cell culture</topic><topic>Cell Differentiation - radiation effects</topic><topic>Cell division</topic><topic>Cell Division - radiation effects</topic><topic>Cell Line</topic><topic>Chemical compounds</topic><topic>Collagen</topic><topic>Electric fields</topic><topic>Electromagnetism</topic><topic>Electrostatic properties</topic><topic>Experiments</topic><topic>Gene expression</topic><topic>Growth factors</topic><topic>High voltage</topic><topic>Humans</topic><topic>Influence</topic><topic>Magnetic Field Therapy</topic><topic>Osteoblastogenesis</topic><topic>Osteoblasts</topic><topic>Osteoblasts - metabolism</topic><topic>Osteoblasts - radiation effects</topic><topic>Osteocalcin</topic><topic>Osteocalcin - metabolism</topic><topic>Regeneration</topic><topic>Regeneration (physiology)</topic><topic>Stainless steel</topic><topic>Static Electricity</topic><topic>Stem cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Su, Chen-Ying</creatorcontrib><creatorcontrib>Fang, Hsu-Wei</creatorcontrib><creatorcontrib>Fang, Tzan</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East &amp; Africa Database</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest advanced technologies &amp; aerospace journals</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Su, Chen-Ying</au><au>Fang, Hsu-Wei</au><au>Fang, Tzan</au><au>Wang, Liping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Electrostatic Field on Osteoblast Cells for Bone Regeneration Applications</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>2017</volume><issue>2017</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Many external stimulations have been shown to promote bone regeneration. The effects of an alternating current (AC) electrostatic field, one of external stimulations, generated from a device with high voltage and low current output on human osteoblastic cell line have been investigated in this study. We investigated how human osteoblasts responded to an AC electrostatic field, and the output parameters were set as 1 kV and 160 μA. Our results showed that, under such condition, the AC electrostatic field had a downregulation effect on the production ability of alkaline phosphatase and type 1 collagen expression. However, the expression of osteocalcin gene was elevated on the end of EFID treatment suggesting that AC electrostatic field might be a potential stimulation for accelerating the differentiation of osteoblastic cells.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>29259985</pmid><doi>10.1155/2017/7124817</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8931-8434</orcidid><orcidid>https://orcid.org/0000-0001-7865-9145</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2314-6133
ispartof BioMed research international, 2017-01, Vol.2017 (2017), p.1-9
issn 2314-6133
2314-6141
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5702948
source Publicly Available Content (ProQuest); Wiley Open Access
subjects Alkaline phosphatase
Alternating current
Aluminum
Biocompatibility
Bone growth
Bone marrow
Bone regeneration
Bone Regeneration - radiation effects
Cell culture
Cell Differentiation - radiation effects
Cell division
Cell Division - radiation effects
Cell Line
Chemical compounds
Collagen
Electric fields
Electromagnetism
Electrostatic properties
Experiments
Gene expression
Growth factors
High voltage
Humans
Influence
Magnetic Field Therapy
Osteoblastogenesis
Osteoblasts
Osteoblasts - metabolism
Osteoblasts - radiation effects
Osteocalcin
Osteocalcin - metabolism
Regeneration
Regeneration (physiology)
Stainless steel
Static Electricity
Stem cells
title Effects of Electrostatic Field on Osteoblast Cells for Bone Regeneration Applications
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T18%3A32%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20Electrostatic%20Field%20on%20Osteoblast%20Cells%20for%20Bone%20Regeneration%20Applications&rft.jtitle=BioMed%20research%20international&rft.au=Su,%20Chen-Ying&rft.date=2017-01-01&rft.volume=2017&rft.issue=2017&rft.spage=1&rft.epage=9&rft.pages=1-9&rft.issn=2314-6133&rft.eissn=2314-6141&rft_id=info:doi/10.1155/2017/7124817&rft_dat=%3Cgale_pubme%3EA557302597%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c499t-25642b4d3ee8b7dc7c54eafc7637ff332e5ee5768f5a429177fb4751c13296f13%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1969051286&rft_id=info:pmid/29259985&rft_galeid=A557302597&rfr_iscdi=true