Clot Structure and Fibrinolysis in Thrombosis and Hemostasis

• Published in: BioMed research international 2017-01, Vol.2017, p.4645137-2
• Main Authors: Bagoly, Zsuzsa, Ariëns, Robert A. S., Rijken, Dingeman C., Pieters, Marlien, Wolberg, Alisa S.
• Format: Article
• Language: English
• Subjects: Angiogenesis; Animals; Blood clot; Blood clots; Care and treatment; Cerebrovascular system; Diagnosis; Efficiency; Fibrinolysis; Hemostasis; Hemostatics; Humans; Laboratories; Mortality; Risk factors; Studies; Thromboembolism; Thrombosis; Thrombosis - metabolism; Wound healing
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2017/4645137

Zsuzsa Bagoly [1] and Robert A. S. Ariëns [2] and Dingeman C. Rijken [3] and Marlien Pieters [4] and Alisa S. Wolberg [5] 1, Department of Laboratory Medicine, Division of Clinical Laboratory Sciences and MTA-DE Cerebrovascular and Neurodegenerative Research Group, University of Debrecen, Debrecen, Hungary, unideb.hu 2, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK, leeds.ac.uk 3, Department of Hematology, Erasmus University Medical Center, Rotterdam, Netherlands, erasmusmc.nl 4, Centre of Excellence for Nutrition (CEN), North-West University, Potchefstroom, South Africa, nwu.ac.za 5, Department of Pathology and Laboratory Medicine and McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA, unc.edu Received Oct 25, 2017; Accepted Oct 26, 2017 This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.The fibrinolytic efficiency of these liposomes was found to be improved in the dynamic fibrinolytic assay under conditions of permeation-driven fibrinolysis.Because intravascular thrombi are exposed to permeation forces, these properties of the construct suggest that it could be a successful candidate as a therapeutic tool, the utility of which deserves further investigation.After measuring a comprehensive set of fibrinolytic and hemostasis proteins in intracardiac and peripheral blood samples from AF patients and non-AF controls, the authors concluded that AF patients have elevated factor VIII and von Willebrand factor levels, present in the intracardiac and peripheral environment as well, possibly contributing to the increased thrombotic risk associated with this disorder.