Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments

High-throughput screening and activity-guided purification identified nicoyamycin A, a natural product comprised of an uncommon 3-methyl-1,4-dioxane ring incorporated into a desferrioxamine-like backbone via a spiroaminal linkage. Nicoyamycin A potently inhibits uropathogenic Escherichia coli growth...

Full description

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2017-11, Vol.53 (95), p.12778-12781
Main Authors: Mike, Laura A, Tripathi, Ashootosh, Blankenship, Connor M, Saluk, Alyssa, Schultz, Pamela J, Tamayo-Castillo, Giselle, Sherman, David H, Mobley, Harry L T
Format: Article
Language:English
Subjects:
Antibiotics
Bacteria
bacterial infections
Bacterial proteins
chemical reactions
dioxane
E coli
Iron
screening
uropathogenic Escherichia coli
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c480t-fdab5f92664211e9c609f7868596659b98084b15de70243e890723b7cedbc1d3
cites cdi_FETCH-LOGICAL-c480t-fdab5f92664211e9c609f7868596659b98084b15de70243e890723b7cedbc1d3
container_end_page 12781
container_issue 95
container_start_page 12778
container_title Chemical communications (Cambridge, England)
container_volume 53
creator Mike, Laura A
Tripathi, Ashootosh
Blankenship, Connor M
Saluk, Alyssa
Schultz, Pamela J
Tamayo-Castillo, Giselle
Sherman, David H
Mobley, Harry L T
description High-throughput screening and activity-guided purification identified nicoyamycin A, a natural product comprised of an uncommon 3-methyl-1,4-dioxane ring incorporated into a desferrioxamine-like backbone via a spiroaminal linkage. Nicoyamycin A potently inhibits uropathogenic Escherichia coli growth in low iron medium, a promising step toward developing novel antibiotics to treat recalcitrant bacterial infections.
doi_str_mv 10.1039/c7cc07732g
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5706644</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1964698244</sourcerecordid><originalsourceid>FETCH-LOGICAL-c480t-fdab5f92664211e9c609f7868596659b98084b15de70243e890723b7cedbc1d3</originalsourceid><addsrcrecordid>eNqFkU1v1DAQhi0EoqVw4QcgS1wQIuDvj0ulKpSCVIlLD9wsx3E2XiX2Yidb7b_H25YKuOCDZ6R5_I5nXgBeY_QRI6o_OekckpKSzRNwiqlgDWfqx9NjznUjKeMn4EUpW1QP5uo5OCEaU800OwXbz6G4tPf5ANMAY3DpYOeDCxFefIA2whDH0IUl5WN5zWlnlzFtfAXhZXGjz8GNwUKXpgA3Od0uY30Cp3QLQ04R-rg_xtnHpbwEzwY7Ff_qIZ6Bmy-XN-3X5vr71bf24rpxTKGlGXrb8UETIRjB2GsnkB6kEoprIbjutEKKdZj3XiLCqFcaSUI76XzfOdzTM3B-L7tbu9n3rrbOdjK7HGabDybZYP6uxDCaTdobLlHtyarAuweBnH6uvixmrjvy02SjT2sxhEisqMT1-h-KtWBCK3Kn-vYfdJvWHOsiDEG4jiQEkZV6f0-5nErJfnj8N0bmaLZpZdvemX1V4Td_TvqI_naX_gJXOKWo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2010846627</pqid></control><display><type>article</type><title>Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments</title><source>Royal Society of Chemistry:Jisc Collections:Royal Society of Chemistry Read and Publish 2022-2024 (reading list)</source><creator>Mike, Laura A ; Tripathi, Ashootosh ; Blankenship, Connor M ; Saluk, Alyssa ; Schultz, Pamela J ; Tamayo-Castillo, Giselle ; Sherman, David H ; Mobley, Harry L T</creator><creatorcontrib>Mike, Laura A ; Tripathi, Ashootosh ; Blankenship, Connor M ; Saluk, Alyssa ; Schultz, Pamela J ; Tamayo-Castillo, Giselle ; Sherman, David H ; Mobley, Harry L T</creatorcontrib><description>High-throughput screening and activity-guided purification identified nicoyamycin A, a natural product comprised of an uncommon 3-methyl-1,4-dioxane ring incorporated into a desferrioxamine-like backbone via a spiroaminal linkage. Nicoyamycin A potently inhibits uropathogenic Escherichia coli growth in low iron medium, a promising step toward developing novel antibiotics to treat recalcitrant bacterial infections.</description><identifier>ISSN: 1359-7345</identifier><identifier>ISSN: 1364-548X</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/c7cc07732g</identifier><identifier>PMID: 29139494</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Antibiotics ; Bacteria ; bacterial infections ; Bacterial proteins ; chemical reactions ; dioxane ; E coli ; Iron ; screening ; uropathogenic Escherichia coli</subject><ispartof>Chemical communications (Cambridge, England), 2017-11, Vol.53 (95), p.12778-12781</ispartof><rights>Copyright Royal Society of Chemistry 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-fdab5f92664211e9c609f7868596659b98084b15de70243e890723b7cedbc1d3</citedby><cites>FETCH-LOGICAL-c480t-fdab5f92664211e9c609f7868596659b98084b15de70243e890723b7cedbc1d3</cites><orcidid>0000-0001-9195-7665 ; 0000-0002-3368-4184 ; 0000-0003-2297-8088 ; 0000-0001-8334-3647 ; 0000-0002-4912-8895</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29139494$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mike, Laura A</creatorcontrib><creatorcontrib>Tripathi, Ashootosh</creatorcontrib><creatorcontrib>Blankenship, Connor M</creatorcontrib><creatorcontrib>Saluk, Alyssa</creatorcontrib><creatorcontrib>Schultz, Pamela J</creatorcontrib><creatorcontrib>Tamayo-Castillo, Giselle</creatorcontrib><creatorcontrib>Sherman, David H</creatorcontrib><creatorcontrib>Mobley, Harry L T</creatorcontrib><title>Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments</title><title>Chemical communications (Cambridge, England)</title><addtitle>Chem Commun (Camb)</addtitle><description>High-throughput screening and activity-guided purification identified nicoyamycin A, a natural product comprised of an uncommon 3-methyl-1,4-dioxane ring incorporated into a desferrioxamine-like backbone via a spiroaminal linkage. Nicoyamycin A potently inhibits uropathogenic Escherichia coli growth in low iron medium, a promising step toward developing novel antibiotics to treat recalcitrant bacterial infections.</description><subject>Antibiotics</subject><subject>Bacteria</subject><subject>bacterial infections</subject><subject>Bacterial proteins</subject><subject>chemical reactions</subject><subject>dioxane</subject><subject>E coli</subject><subject>Iron</subject><subject>screening</subject><subject>uropathogenic Escherichia coli</subject><issn>1359-7345</issn><issn>1364-548X</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqFkU1v1DAQhi0EoqVw4QcgS1wQIuDvj0ulKpSCVIlLD9wsx3E2XiX2Yidb7b_H25YKuOCDZ6R5_I5nXgBeY_QRI6o_OekckpKSzRNwiqlgDWfqx9NjznUjKeMn4EUpW1QP5uo5OCEaU800OwXbz6G4tPf5ANMAY3DpYOeDCxFefIA2whDH0IUl5WN5zWlnlzFtfAXhZXGjz8GNwUKXpgA3Od0uY30Cp3QLQ04R-rg_xtnHpbwEzwY7Ff_qIZ6Bmy-XN-3X5vr71bf24rpxTKGlGXrb8UETIRjB2GsnkB6kEoprIbjutEKKdZj3XiLCqFcaSUI76XzfOdzTM3B-L7tbu9n3rrbOdjK7HGabDybZYP6uxDCaTdobLlHtyarAuweBnH6uvixmrjvy02SjT2sxhEisqMT1-h-KtWBCK3Kn-vYfdJvWHOsiDEG4jiQEkZV6f0-5nErJfnj8N0bmaLZpZdvemX1V4Td_TvqI_naX_gJXOKWo</recordid><startdate>20171128</startdate><enddate>20171128</enddate><creator>Mike, Laura A</creator><creator>Tripathi, Ashootosh</creator><creator>Blankenship, Connor M</creator><creator>Saluk, Alyssa</creator><creator>Schultz, Pamela J</creator><creator>Tamayo-Castillo, Giselle</creator><creator>Sherman, David H</creator><creator>Mobley, Harry L T</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9195-7665</orcidid><orcidid>https://orcid.org/0000-0002-3368-4184</orcidid><orcidid>https://orcid.org/0000-0003-2297-8088</orcidid><orcidid>https://orcid.org/0000-0001-8334-3647</orcidid><orcidid>https://orcid.org/0000-0002-4912-8895</orcidid></search><sort><creationdate>20171128</creationdate><title>Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments</title><author>Mike, Laura A ; Tripathi, Ashootosh ; Blankenship, Connor M ; Saluk, Alyssa ; Schultz, Pamela J ; Tamayo-Castillo, Giselle ; Sherman, David H ; Mobley, Harry L T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-fdab5f92664211e9c609f7868596659b98084b15de70243e890723b7cedbc1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Antibiotics</topic><topic>Bacteria</topic><topic>bacterial infections</topic><topic>Bacterial proteins</topic><topic>chemical reactions</topic><topic>dioxane</topic><topic>E coli</topic><topic>Iron</topic><topic>screening</topic><topic>uropathogenic Escherichia coli</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mike, Laura A</creatorcontrib><creatorcontrib>Tripathi, Ashootosh</creatorcontrib><creatorcontrib>Blankenship, Connor M</creatorcontrib><creatorcontrib>Saluk, Alyssa</creatorcontrib><creatorcontrib>Schultz, Pamela J</creatorcontrib><creatorcontrib>Tamayo-Castillo, Giselle</creatorcontrib><creatorcontrib>Sherman, David H</creatorcontrib><creatorcontrib>Mobley, Harry L T</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mike, Laura A</au><au>Tripathi, Ashootosh</au><au>Blankenship, Connor M</au><au>Saluk, Alyssa</au><au>Schultz, Pamela J</au><au>Tamayo-Castillo, Giselle</au><au>Sherman, David H</au><au>Mobley, Harry L T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2017-11-28</date><risdate>2017</risdate><volume>53</volume><issue>95</issue><spage>12778</spage><epage>12781</epage><pages>12778-12781</pages><issn>1359-7345</issn><issn>1364-548X</issn><eissn>1364-548X</eissn><abstract>High-throughput screening and activity-guided purification identified nicoyamycin A, a natural product comprised of an uncommon 3-methyl-1,4-dioxane ring incorporated into a desferrioxamine-like backbone via a spiroaminal linkage. Nicoyamycin A potently inhibits uropathogenic Escherichia coli growth in low iron medium, a promising step toward developing novel antibiotics to treat recalcitrant bacterial infections.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>29139494</pmid><doi>10.1039/c7cc07732g</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0001-9195-7665</orcidid><orcidid>https://orcid.org/0000-0002-3368-4184</orcidid><orcidid>https://orcid.org/0000-0003-2297-8088</orcidid><orcidid>https://orcid.org/0000-0001-8334-3647</orcidid><orcidid>https://orcid.org/0000-0002-4912-8895</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1359-7345
ispartof Chemical communications (Cambridge, England), 2017-11, Vol.53 (95), p.12778-12781
issn 1359-7345
1364-548X
1364-548X
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5706644
source Royal Society of Chemistry:Jisc Collections:Royal Society of Chemistry Read and Publish 2022-2024 (reading list)
subjects Antibiotics
Bacteria
bacterial infections
Bacterial proteins
chemical reactions
dioxane
E coli
Iron
screening
uropathogenic Escherichia coli
title Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T07%3A41%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Discovery%20of%20nicoyamycin%20A,%20an%20inhibitor%20of%20uropathogenic%20Escherichia%20coli%20growth%20in%20low%20iron%20environments&rft.jtitle=Chemical%20communications%20(Cambridge,%20England)&rft.au=Mike,%20Laura%20A&rft.date=2017-11-28&rft.volume=53&rft.issue=95&rft.spage=12778&rft.epage=12781&rft.pages=12778-12781&rft.issn=1359-7345&rft.eissn=1364-548X&rft_id=info:doi/10.1039/c7cc07732g&rft_dat=%3Cproquest_pubme%3E1964698244%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c480t-fdab5f92664211e9c609f7868596659b98084b15de70243e890723b7cedbc1d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2010846627&rft_id=info:pmid/29139494&rfr_iscdi=true