Methylated claudin-11 associated with metastasis and poor survival of colorectal cancer

As one of crucial epigenetic modification, DNA methylation plays an important role during the carcinogenesis of colorectal cancer (CRC). In the current study, we used a human genome methylation array to detect the aberrant methylation genes in CRC. We further identified the hypermethylation of ( ) a...

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Published in:Oncotarget 2017-11, Vol.8 (56), p.96249-96262
Main Authors: Li, Jinyun, Zhou, Chongchang, Ni, Shumin, Wang, Shaomin, Ni, Chao, Yang, Ping, Ye, Meng
Format: Article
Language:English
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Research Paper
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Summary:As one of crucial epigenetic modification, DNA methylation plays an important role during the carcinogenesis of colorectal cancer (CRC). In the current study, we used a human genome methylation array to detect the aberrant methylation genes in CRC. We further identified the hypermethylation of ( ) and proved inverse correlation between methylation and its expression in CRC. experiments showed debased migration ability of colonic cancer cells in accompany with the converted methylation of after colonic cancer cells treated with demethylation agent, 5-aza-2'-deoxycytidine. Besides, our results also represented that hypermethylation of was associated with increased metastatic potential of CRC and with low progression free survival (PFS) of CRC. In conclusion, our findings supported that the hypermethylated is associated with metastasis of CRC and prognosis of poor survival of CRC.
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.21997