Anserine/Carnosine Supplementation Suppresses the Expression of the Inflammatory Chemokine CCL24 in Peripheral Blood Mononuclear Cells from Elderly People

Our goal was to determine whether anserine/carnosine supplementation (ACS) suppresses chemokine levels in elderly people. In a double-blind randomized controlled trial, volunteers were assigned to the ACS or placebo group (1:1). Sixty healthy elderly volunteers (active, = 30; placebo, = 30) complete...

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Bibliographic Details
Published in:Nutrients 2017-10, Vol.9 (11), p.1199
Main Authors: Katakura, Yoshinori, Totsuka, Mamoru, Imabayashi, Etsuko, Matsuda, Hiroshi, Hisatsune, Tatsuhiro
Format: Article
Language:English
Subjects:
anserine
Blood
Carnosine
chemokine CCL24
Chemokines
elderly
Geriatrics
Inflammation
Leukocytes (mononuclear)
memory
microarray technology
mononuclear leukocytes
Older people
Peripheral blood mononuclear cells
placebos
Polymerase chain reaction
Preservation
quantitative polymerase chain reaction
randomized clinical trials
reverse transcriptase polymerase chain reaction
T cell receptors
volunteers
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Summary:Our goal was to determine whether anserine/carnosine supplementation (ACS) suppresses chemokine levels in elderly people. In a double-blind randomized controlled trial, volunteers were assigned to the ACS or placebo group (1:1). Sixty healthy elderly volunteers (active, = 30; placebo, = 30) completed the study. The ACS group was administered 1.0 g of anserine/carnosine (3:1) for 3 months. A microarray analysis and subsequent quantitative real-time polymerase chain reaction (qRT-PCR) analysis of peripheral blood mononuclear cells (PBMCs) showed decreased expression of CCL24, an inflammatory chemokine ( < 0.05). Verbal memory, assessed using the Wechsler memory scale-logical memory, was preserved in the ACS group. An age-restricted sub-analysis showed significant verbal memory preservation by ACS in participants who were in their 60s (active, = 12; placebo, = 9; = 0.048) and 70s (active, = 7; placebo, = 11; = 0.017). The suppression of CCL24 expression was greatest in people who were in their 70s ( < 0.01). There was a significant correlation between the preservation of verbal memory and suppression of CCL24 expression in the group that was in the 70s (Poisson correlation, = 0.46, < 0.05). These results suggest that ACS may preserve verbal episodic memory, probably owing to CCL24 suppression in the blood, especially in elderly participants.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu9111199