Detection of adamantane-sensitive influenza A(H3N2) viruses in Australia, 2017: a cause for hope?

For over a decade virtually all A(H3N2) influenza viruses have been resistant to the adamantane class of antivirals. However, during the 2017 influenza season in Australia, 15/461 (3.3%) adamantane-sensitive A(H3N2) viruses encoding serine at residue 31 of the M2 protein were detected, more than the...

Full description

Saved in:
Bibliographic Details
Published in:Euro surveillance : bulletin européen sur les maladies transmissibles 2017-11, Vol.22 (47)
Main Authors: Hurt, Aeron, Komadina, Naomi, Deng, Yi-Mo, Kaye, Matthew, Sullivan, Sheena, Subbarao, Kanta, Barr, Ian
Format: Article
Language:English
Subjects:
Adamantane - pharmacology
Amino Acid Substitution
Antiviral Agents - pharmacology
Australia - epidemiology
Disease transmission
Drug Resistance, Viral - genetics
Genome, Viral
Humans
Influenza
Influenza A Virus, H3N2 Subtype - drug effects
Influenza A Virus, H3N2 Subtype - genetics
Influenza A Virus, H3N2 Subtype - isolation & purification
Influenza, Human - drug therapy
Influenza, Human - epidemiology
Influenza, Human - virology
Medical treatment
Phylogeny
Rapid Communication
RNA, Viral
Seasons
Sequence Analysis, DNA
Travel medicine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:For over a decade virtually all A(H3N2) influenza viruses have been resistant to the adamantane class of antivirals. However, during the 2017 influenza season in Australia, 15/461 (3.3%) adamantane-sensitive A(H3N2) viruses encoding serine at residue 31 of the M2 protein were detected, more than the total number identified globally during the last 6 years. A return to wide circulation of adamantane-sensitive A(H3N2) viruses would revive the option of using these drugs for treatment and prophylaxis.
ISSN:1560-7917
1025-496X
1560-7917
DOI:10.2807/1560-7917.es.2017.22.47.17-00731