MRI findings of radiation-induced changes in the urethra and periurethral tissues after treatment for prostate cancer

Abstract Purpose To assess radiotherapy (RT)-induced changes in the urethra and periurethral tissues after treatment for prostate cancer (PCa). Methods and materials This retrospective study included 108 men (median age, 64 years; range, 43–87 years) who received external-beam radiotherapy (EBRT) an...

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Bibliographic Details
Published in:European journal of radiology 2013-12, Vol.82 (12), p.e775-e781
Main Authors: Marigliano, Chiara, Donati, Olivio F, Vargas, Hebert Alberto, Akin, Oguz, Goldman, Debra A, Eastham, James A, Zelefsky, Michael J, Hricak, Hedvig
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Comorbidity
Humans
Incidence
Magnetic Resonance Imaging
Male
Middle Aged
MRI
New York - epidemiology
Prostate cancer, Urethra
Prostatic Neoplasms - epidemiology
Prostatic Neoplasms - pathology
Prostatic Neoplasms - radiotherapy
Radiation Injuries - epidemiology
Radiation Injuries - pathology
Radiation therapy
Radiology
Radiotherapy, Adjuvant - statistics & numerical data
Retrospective Studies
Risk Factors
Urethra - injuries
Urethra - pathology
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Summary:Abstract Purpose To assess radiotherapy (RT)-induced changes in the urethra and periurethral tissues after treatment for prostate cancer (PCa). Methods and materials This retrospective study included 108 men (median age, 64 years; range, 43–87 years) who received external-beam radiotherapy (EBRT) and/or brachytherapy for PCa and underwent endorectal-coil MRI of the prostate within 180 days before RT and a median of 20 months (range, 2–62 months) after RT. On all MRIs, two readers independently measured the urethral length (UL) and graded the margin definition (MD) of the urethral wall and the signal intensities (SIs) of the urethral wall and pelvic muscles on 4-point scales. Results The mean urethral length decreased significantly from pre- to post-RT MRI (from 15.2 to 12.6 mm and from 14.4 to 12.9 mm for readers 1 and 2, respectively; both p -values
ISSN:0720-048X
1872-7727
DOI:10.1016/j.ejrad.2013.09.011