Long noncoding RNAs: a new regulatory code in osteoarthritis

It is reported that long noncoding RNAs (lncRNAs) were expressed aberrantly in cartilage of osteoarthritis (OA). Current evidence indicates that lncRNAs not only serve as positive or negative regulators of OA, but also crosstalk with multiple potential targets to impact on the critical events in OA...

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Published in:American journal of translational research 2017-01, Vol.9 (11), p.4747-4755
Main Authors: Cen, Xiao, Huang, Xin-Qi, Sun, Wen-Tian, Liu, Qing, Liu, Jun
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Huang, Xin-Qi
Sun, Wen-Tian
Liu, Qing
Liu, Jun
description It is reported that long noncoding RNAs (lncRNAs) were expressed aberrantly in cartilage of osteoarthritis (OA). Current evidence indicates that lncRNAs not only serve as positive or negative regulators of OA, but also crosstalk with multiple potential targets to impact on the critical events in OA process. This review summarized the lncRNAs identified in OA to date, discussed their influence on the survival of chondrocytes and synoviocytes, arthritis-associated factors, and angiogenesis, and indicated the potential in diagnosis, therapy, and prognosis.
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title Long noncoding RNAs: a new regulatory code in osteoarthritis
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