In vitro and in vivo antifungal activities and mechanism of heteropolytungstates against Candida species

• Published in: Scientific reports 2017-12, Vol.7 (1), p.16942-9, Article 16942
• Main Authors: Li, Han, Gong, Hongwei, Qi, Yanfei, Li, Juan, Ji, Xufeng, Sun, Jiaheng, Tian, Rui, Bao, Hao, Song, Xiangfu, Chen, Qiang, Liu, Guoliang
• Format: Article
• Language: English
• Subjects: 38/77; 631/326/22/1292; 692/308/153; Acute toxicity; Animals; Antifungal activity; Antifungal Agents - adverse effects; Antifungal Agents - chemistry; Antifungal Agents - pharmacology; Biosynthesis; Candida; Candida - drug effects; Candida - genetics; Candida - metabolism; Candida albicans; Candida albicans - drug effects; Candida albicans - pathogenicity; Candida albicans - ultrastructure; Candidiasis - drug therapy; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; Ergosterol; Ergosterol - analysis; Ergosterol - biosynthesis; Fungal infections; Gene expression; Humanities and Social Sciences; Lethal dose; Mice, Inbred BALB C; Mice, Inbred ICR; Microbial Sensitivity Tests; Microscopy, Electron, Transmission; Minimum inhibitory concentration; Mode of action; Morbidity; multidisciplinary; Pathogens; Real-Time Polymerase Chain Reaction; Science; Science (multidisciplinary); Toxicity; Toxicity Tests, Acute; Transmission electron microscopy; Tungsten Compounds - chemistry; Tungsten Compounds - pharmacology
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-017-17239-8

The antifungal activities of heteropolytungstates, α-1,2,3-K 6 H[SiW 9 V 3 O 40 ] (SiW-3), K 13 [Ce(SiW 11 O 39 ) 2 ]·17H 2 O (SiW-5), K 13 [Eu(SiW 11 O 39 ) 2 ]·25H 2 O (SiW-10), K 6 PV 3 W 9 O 40 (PW-6), α-K 4 PVW 11 O 40 (PW-8), were screened in 29 Candida albicans , 8 Candida glabrata , 3 Candida krusei , 2 Candida parapsilosis , 1 Candida tropicalis , and 1 Cryptococcus neoformans strains using the CLSI M27-A3 method. SiW-5 had the highest efficacy with a minimum inhibitory concentration (MIC) values of