Effect of initial periodontal therapy on gingival crevicular fluid cytokine profile in subjects with chronic periodontitis

Cytokines are thought to play an important role in the pathogenesis of periodontal disease. Because periodontal disease is known for its inhomogeneous distribution within the dentition, it is unclear to what extent the detection of various cytokines at different sites correlates with presence of dis...

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Bibliographic Details
Published in:Clinical and experimental dental research 2017-04, Vol.3 (2), p.62-68
Main Authors: Zekeridou, A., Giannopoulou, C., Cancela, J., Courvoisier, D., Mombelli, A.
Format: Article
Language:English
Subjects:
Biomarkers
Cytokines
Dental implants
Disease
gingival crevice fluid
Gum disease
Original
periodontal disease
periodontal treatment
Studies
Teeth
Transplants & implants
Tumor necrosis factor-TNF
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Summary:Cytokines are thought to play an important role in the pathogenesis of periodontal disease. Because periodontal disease is known for its inhomogeneous distribution within the dentition, it is unclear to what extent the detection of various cytokines at different sites correlates with presence of disease. We evaluated whether levels of 12 cytokines in gingival crevicular fluid (GCF) discriminated periodontally diseased sites from healthy ones, or periodontally diseased persons from healthy ones, and assessed the impact of nonsurgical periodontal therapy on these readings. This study included 20 periodontally healthy persons (H) and 24 patients with chronic periodontitis (P). In every participant, we measured the plaque index, gingival index, probing pocket depth (PD), bleeding on probing, and recession at six sites of every tooth. GCF was collected with Durapore® filter strips from two healthy sites (PD
ISSN:2057-4347
2057-4347
DOI:10.1002/cre2.61