Universal Patterns of Selection in Cancer and Somatic Tissues

Cancer develops as a result of somatic mutation and clonal selection, but quantitative measures of selection in cancer evolution are lacking. We adapted methods from molecular evolution and applied them to 7,664 tumors across 29 cancer types. Unlike species evolution, positive selection outweighs ne...

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Bibliographic Details
Published in:Cell 2017-11, Vol.171 (5), p.1029-1041.e21
Main Authors: Martincorena, Iñigo, Raine, Keiran M., Gerstung, Moritz, Dawson, Kevin J., Haase, Kerstin, Van Loo, Peter, Davies, Helen, Stratton, Michael R., Campbell, Peter J.
Format: Article
Language:English
Subjects:
cancer
evolution
genomics
Humans
INDEL Mutation
Microsatellite Instability
Models, Genetic
Mutation Rate
mutations
Neoplasms - genetics
Neoplasms - immunology
Neoplasms - pathology
Point Mutation
Polymorphism, Single Nucleotide
selection
Selection, Genetic
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Summary:Cancer develops as a result of somatic mutation and clonal selection, but quantitative measures of selection in cancer evolution are lacking. We adapted methods from molecular evolution and applied them to 7,664 tumors across 29 cancer types. Unlike species evolution, positive selection outweighs negative selection during cancer development. On average,
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2017.09.042