Long‐term survival after surveillance and treatment in patients with chronic viral hepatitis and hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the main cause of mortality in patients with chronic viral hepatitis (CVH). We determined the impact of surveillance and treatments on long‐term outcomes in patients with CVH who developed HCC. Between 1984 and 2014, 333 patients with HCC and with hepatitis B or hep...

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Bibliographic Details
Published in:Hepatology communications 2017-09, Vol.1 (7), p.595-608
Main Authors: Tong, Myron J., Rosinski, Alexander A., Huynh, Claiborne T., Raman, Steven S., Lu, David S.K.
Format: Article
Language:English
Subjects:
Abdomen
Antigens
Cancer therapies
Hepatitis
Infections
Liver cancer
Liver diseases
Medical prognosis
Mortality
NMR
Nuclear magnetic resonance
Original
Patients
Studies
Surveillance
Tumors
Ultrasonic imaging
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Summary:Hepatocellular carcinoma (HCC) is the main cause of mortality in patients with chronic viral hepatitis (CVH). We determined the impact of surveillance and treatments on long‐term outcomes in patients with CVH who developed HCC. Between 1984 and 2014, 333 patients with HCC and with hepatitis B or hepatitis C virus infection were evaluated. An adjusted lead time bias interval was added to patients with HCC who presented with HCC (no surveillance), and their survival was compared to patients whose HCC was detected by surveillance. After HCC treatments, survival rates within and beyond 3 years of follow‐up were compared. In 175 (53%) patients, HCC was detected through surveillance using alpha‐fetoprotein and abdominal ultrasound examinations. Compared to 158 (47%) patients with HCC who had no surveillance, more patients with HCC detected by surveillance received surgical and locoregional treatments (P 
ISSN:2471-254X
2471-254X
DOI:10.1002/hep4.1047