Association of PPARG rs 1801282 C>G polymorphism with risk of colorectal cancer: from a case-control study to a meta-analysis

• Published in: Oncotarget 2017-11, Vol.8 (59), p.100558-100569
• Main Authors: Jiang, Jiakai, Xie, Zhiqiang, Guo, JunYing, Wang, Yafeng, Liu, Chao, Zhang, Sheng, Tang, Weifeng, Chen, Yu
• Format: Article
• Language: English
• Subjects: Meta-Analysis
• ISSN: 1949-2553; 1949-2553
• DOI: 10.18632/oncotarget.20138

The functional single nucleotide polymorphisms in ( ) gene were predicted to be correlated with the susceptibility of colorectal cancer (CRC). The aim of the present study was to explore the relationship between rs1801282 C>G polymorphism and the risk of CRC. First, we conducted a case-control study with 387 CRC cases and 1,536 controls. We used the SNPscan method to determine the genotypes of rs1801282 C>G polymorphism. We found rs1801282 C>G polymorphism had a tendency of decreased risk to CRC risk (CG vs. CC: adjusted OR, 0.67, 95% CI = 0.43-1.04 for CG vs. CC, = 0.073; GG vs. CC: adjusted OR, 0.68; 95% CI, 0.44-1.05; = 0.078). The stratified analysis revealed rs1801282 C>G polymorphism also had a tendency of decreased risk to colon cancer (CG . CC: adjusted OR = 0.54, 95% CI = 0.27-1.08, = 0.083). The results of subsequent meta-analysis suggested that rs1801282 C>G polymorphism might be a protective factor for CRC, especially in Asians, colon cancer and rectum cancer subgroups. In conclusion, our study indicates that rs1801282 C>G polymorphism might decrease the risk of overall CRC. Larger sample size and well-designed case-control studies are needed to confirm the potential association.