Drug discovery and development: Role of basic biological research

• Published in: Alzheimer's & dementia : translational research & clinical interventions 2017-11, Vol.3 (4), p.651-657
• Main Authors: Mohs, Richard C., Greig, Nigel H.
• Format: Article
• Language: English
• ISSN: 2352-8737; 2352-8737
• DOI: 10.1016/j.trci.2017.10.005

This article provides a brief overview of the processes of drug discovery and development. Our aim is to help scientists whose research may be relevant to drug discovery and/or development to frame their research report in a way that appropriately places their findings within the drug discovery and development process and thereby support effective translation of preclinical research to humans. One overall theme of our article is that the process is sufficiently long, complex, and expensive so that many biological targets must be considered for every new medicine eventually approved for clinical use and new research tools may be needed to investigate each new target. Studies that contribute to solving any of the many scientific and operational issues involved in the development process can improve the efficiency of the process. An awareness of these issues allows the early implementation of measures to increase the opportunity for success. As editors of the journal, we encourage submission of research reports that provide data relevant to the issues presented.