Cholangiolocellular Carcinoma in a Young Patient Who Showed Sustained Virological Response after Treatment for Hepatitis C Virus Infection

A 35-year-old male patient who showed sustained virological response (SVR) following treatment for hepatitis C virus infection developed liver cancer. The lesion was identified by imaging studies, with atypical findings suggestive of hepatocellular carcinoma. Partial hepatectomy was performed and th...

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Bibliographic Details
Published in:Internal Medicine 2017/11/15, Vol.56(22), pp.3033-3040
Main Authors: Osawa, Mitsutaka, Saitoh, Satoshi, Fujiyama, Shunichiro, Kawamura, Yusuke, Sezaki, Hitomi, Hosaka, Tetsuya, Akuta, Norio, Kobayashi, Masahiro, Suzuki, Yoshiyuki, Suzuki, Fumitaka, Ikeda, Kenji, Kinowaki, Keiichi, Fujii, Takeshi, Fukusato, Toshio, Kondo, Fukuo, Kumada, Hiromitsu
Format: Article
Language:English
Subjects:
Case Report
cholangiolocellular carcinoma
Hepatectomy
Hepatitis
Hepatitis C
hepatitis C virus
Hepatocellular carcinoma
Infections
Internal medicine
Liver
Liver cancer
Patients
sustained virological response
Viruses
young patient
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Summary:A 35-year-old male patient who showed sustained virological response (SVR) following treatment for hepatitis C virus infection developed liver cancer. The lesion was identified by imaging studies, with atypical findings suggestive of hepatocellular carcinoma. Partial hepatectomy was performed and the histopathological diagnosis was cholangiolocellular carcinoma (CLC). Only a few cases of CLC have been described in young patients who achieved SVR. Hepatologists should recognize the potential development of CLC even in young patients who achieve SVR, and the need for a close follow-up by imaging studies. In addition, true characteristics and cell origin of CLC were discussed in this report.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.9021-17