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Insulinoma Presenting with Reactive Hypoglycemia: Evaluating the Effect of Tumor Resection via Continuous Glucose Monitoring
A 71-year-old woman previously diagnosed with reactive hypoglycemia was transferred to our emergency unit because of loss of consciousness. Her plasma glucose level was 27 mg/dL, and continuous glucose monitoring (CGM) revealed postprandial asymptomatic hypoglycemia. A hypervascular tumor was identi...
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Published in: | Internal Medicine 2017/11/15, Vol.56(22), pp.3067-3071 |
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creator | Kikuchi, Tomohiko Chujo, Daisuke Takahashi, Kazuhisa Takahashi, Nobuyuki Tanno, Yuuki Tonoike, Mie Ihana, Noriko Tsujimoto, Tetsuro Tanabe, Akiyo Kajio, Hiroshi |
description | A 71-year-old woman previously diagnosed with reactive hypoglycemia was transferred to our emergency unit because of loss of consciousness. Her plasma glucose level was 27 mg/dL, and continuous glucose monitoring (CGM) revealed postprandial asymptomatic hypoglycemia. A hypervascular tumor was identified via computed tomography in the distal pancreas, and the diagnosis of insulinoma was confirmed using the selective arterial calcium stimulation test. Although no episodes of hypoglycemia were observed during CGM after resection, a pathological examination identified regional lymph node metastasis. It is important to consider insulinoma as a cause of postprandial hypoglycemia, and CGM is useful for evaluating treatment outcomes. |
doi_str_mv | 10.2169/internalmedicine.8766-16 |
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Her plasma glucose level was 27 mg/dL, and continuous glucose monitoring (CGM) revealed postprandial asymptomatic hypoglycemia. A hypervascular tumor was identified via computed tomography in the distal pancreas, and the diagnosis of insulinoma was confirmed using the selective arterial calcium stimulation test. Although no episodes of hypoglycemia were observed during CGM after resection, a pathological examination identified regional lymph node metastasis. It is important to consider insulinoma as a cause of postprandial hypoglycemia, and CGM is useful for evaluating treatment outcomes.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.8766-16</identifier><identifier>PMID: 28943561</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Calcium ; Case Report ; Computed tomography ; continuous glucose monitoring ; Glucose ; Glucose monitoring ; Hypoglycemia ; Insulinoma ; Internal medicine ; Metastases ; metastasis ; Pancreas ; postprandial hypoglycemia</subject><ispartof>Internal Medicine, 2017/11/15, Vol.56(22), pp.3067-3071</ispartof><rights>2017 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2017</rights><rights>Copyright © 2017 by The Japanese Society of Internal Medicine 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c610t-882ab3a502f8fbf72d9ff40892f9c0028f2150a9c5e304e7e6448aae3775e44a3</citedby><cites>FETCH-LOGICAL-c610t-882ab3a502f8fbf72d9ff40892f9c0028f2150a9c5e304e7e6448aae3775e44a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725862/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725862/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28943561$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kikuchi, Tomohiko</creatorcontrib><creatorcontrib>Chujo, Daisuke</creatorcontrib><creatorcontrib>Takahashi, Kazuhisa</creatorcontrib><creatorcontrib>Takahashi, Nobuyuki</creatorcontrib><creatorcontrib>Tanno, Yuuki</creatorcontrib><creatorcontrib>Tonoike, Mie</creatorcontrib><creatorcontrib>Ihana, Noriko</creatorcontrib><creatorcontrib>Tsujimoto, Tetsuro</creatorcontrib><creatorcontrib>Tanabe, Akiyo</creatorcontrib><creatorcontrib>Kajio, Hiroshi</creatorcontrib><title>Insulinoma Presenting with Reactive Hypoglycemia: Evaluating the Effect of Tumor Resection via Continuous Glucose Monitoring</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>A 71-year-old woman previously diagnosed with reactive hypoglycemia was transferred to our emergency unit because of loss of consciousness. Her plasma glucose level was 27 mg/dL, and continuous glucose monitoring (CGM) revealed postprandial asymptomatic hypoglycemia. A hypervascular tumor was identified via computed tomography in the distal pancreas, and the diagnosis of insulinoma was confirmed using the selective arterial calcium stimulation test. Although no episodes of hypoglycemia were observed during CGM after resection, a pathological examination identified regional lymph node metastasis. It is important to consider insulinoma as a cause of postprandial hypoglycemia, and CGM is useful for evaluating treatment outcomes.</description><subject>Calcium</subject><subject>Case Report</subject><subject>Computed tomography</subject><subject>continuous glucose monitoring</subject><subject>Glucose</subject><subject>Glucose monitoring</subject><subject>Hypoglycemia</subject><subject>Insulinoma</subject><subject>Internal medicine</subject><subject>Metastases</subject><subject>metastasis</subject><subject>Pancreas</subject><subject>postprandial hypoglycemia</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNplkVFvFCEUhSdGY7fVv2BIfPFlKjAMAz6YmM3aNqmpMfWZsPSyy2YGVmDWbOKPl-muG60vlxC-c-BwqgoRfEkJl--dzxC97gd4cMZ5uBQd5zXhz6oZaZisO9q0z6sZlkTUtIyz6jylDcaN6CR9WZ1RIVnTcjKrft34NPbOh0GjrxES-Oz8Cv10eY2-gTbZ7QBd77dh1e8NDE5_QIud7kf9iOU1oIW1YDIKFt2PQ4hFlcreBY92TqN5mAzHMCZ01Y8mJEBfgnc5xKJ_Vb2wuk_w-rheVN8_L-7n1_Xt3dXN_NNtbTjBuRaC6mWjW0ytsEvb0QdpLcNCUisNxlRYSlqspWmhwQw64IwJraHpuhYY081F9fHgux2X5ctMCRl1r7bRDTruVdBO_Xvi3Vqtwk61HW0Fp8Xg3dEghh8jpKwGlwz0vfZQoikiGe0I5pgU9O0TdBPGqaukKCasxQ1jvFDiQJkYUopgT48hWE0Vq6cVq6liRSbpm7_DnIR_Oi3A3QHYpKxXcAJ0zM708L9zyxWl0zxecSLNWkcFvvkNbbzINg</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Kikuchi, Tomohiko</creator><creator>Chujo, Daisuke</creator><creator>Takahashi, Kazuhisa</creator><creator>Takahashi, Nobuyuki</creator><creator>Tanno, Yuuki</creator><creator>Tonoike, Mie</creator><creator>Ihana, Noriko</creator><creator>Tsujimoto, Tetsuro</creator><creator>Tanabe, Akiyo</creator><creator>Kajio, Hiroshi</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170101</creationdate><title>Insulinoma Presenting with Reactive Hypoglycemia: Evaluating the Effect of Tumor Resection via Continuous Glucose Monitoring</title><author>Kikuchi, Tomohiko ; Chujo, Daisuke ; Takahashi, Kazuhisa ; Takahashi, Nobuyuki ; Tanno, Yuuki ; Tonoike, Mie ; Ihana, Noriko ; Tsujimoto, Tetsuro ; Tanabe, Akiyo ; Kajio, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c610t-882ab3a502f8fbf72d9ff40892f9c0028f2150a9c5e304e7e6448aae3775e44a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Calcium</topic><topic>Case Report</topic><topic>Computed tomography</topic><topic>continuous glucose monitoring</topic><topic>Glucose</topic><topic>Glucose monitoring</topic><topic>Hypoglycemia</topic><topic>Insulinoma</topic><topic>Internal medicine</topic><topic>Metastases</topic><topic>metastasis</topic><topic>Pancreas</topic><topic>postprandial hypoglycemia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kikuchi, Tomohiko</creatorcontrib><creatorcontrib>Chujo, Daisuke</creatorcontrib><creatorcontrib>Takahashi, Kazuhisa</creatorcontrib><creatorcontrib>Takahashi, Nobuyuki</creatorcontrib><creatorcontrib>Tanno, Yuuki</creatorcontrib><creatorcontrib>Tonoike, Mie</creatorcontrib><creatorcontrib>Ihana, Noriko</creatorcontrib><creatorcontrib>Tsujimoto, Tetsuro</creatorcontrib><creatorcontrib>Tanabe, Akiyo</creatorcontrib><creatorcontrib>Kajio, Hiroshi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kikuchi, Tomohiko</au><au>Chujo, Daisuke</au><au>Takahashi, Kazuhisa</au><au>Takahashi, Nobuyuki</au><au>Tanno, Yuuki</au><au>Tonoike, Mie</au><au>Ihana, Noriko</au><au>Tsujimoto, Tetsuro</au><au>Tanabe, Akiyo</au><au>Kajio, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulinoma Presenting with Reactive Hypoglycemia: Evaluating the Effect of Tumor Resection via Continuous Glucose Monitoring</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>56</volume><issue>22</issue><spage>3067</spage><epage>3071</epage><pages>3067-3071</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>A 71-year-old woman previously diagnosed with reactive hypoglycemia was transferred to our emergency unit because of loss of consciousness. Her plasma glucose level was 27 mg/dL, and continuous glucose monitoring (CGM) revealed postprandial asymptomatic hypoglycemia. A hypervascular tumor was identified via computed tomography in the distal pancreas, and the diagnosis of insulinoma was confirmed using the selective arterial calcium stimulation test. Although no episodes of hypoglycemia were observed during CGM after resection, a pathological examination identified regional lymph node metastasis. It is important to consider insulinoma as a cause of postprandial hypoglycemia, and CGM is useful for evaluating treatment outcomes.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>28943561</pmid><doi>10.2169/internalmedicine.8766-16</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Calcium Case Report Computed tomography continuous glucose monitoring Glucose Glucose monitoring Hypoglycemia Insulinoma Internal medicine Metastases metastasis Pancreas postprandial hypoglycemia |
title | Insulinoma Presenting with Reactive Hypoglycemia: Evaluating the Effect of Tumor Resection via Continuous Glucose Monitoring |
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