Clinical feature and management of immune thrombocytopenic purpura in a tertiary hospital in Northwest Nigeria

Immune thrombocytopenic purpura (ITP) is a rare bleeding disorder that may remit spontaneously. Life-threatening bleeding may require transfusion support, steroids, and other immunosuppressive therapy or splenectomy. To review the clinical presentation and laboratory features of ITP at Ahmadu Bello...

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Published in:Nigerian medical journal 2017-03, Vol.58 (2), p.68-71
Main Authors: Hassan, Abdulaziz, Adebayo, Adeshola, Musa, Abubakar Umar, Suleiman, Aishatu Maude, Ibrahim, Ismaila Nda, Kusfa, Ibrahim Usman, Aminu, Mohammed Sirajo
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Thrombocytopenic purpura
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container_title Nigerian medical journal
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creator Hassan, Abdulaziz
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description Immune thrombocytopenic purpura (ITP) is a rare bleeding disorder that may remit spontaneously. Life-threatening bleeding may require transfusion support, steroids, and other immunosuppressive therapy or splenectomy. To review the clinical presentation and laboratory features of ITP at Ahmadu Bello University Teaching Hospital (ABUTH), Zaria, Nigeria. A retrospective analytic study of case notes and bone marrow (BM) records of patients diagnosed with ITP at Haematology Department, ABUTH, Zaria, from January 1, 2004, to December 31, 2012. There were nine cases (six females, three males), aged 6-20 (mean 11.11) years. The presentations were epistaxis 8 (88.9%), purpura 4 (44.4%), gum bleeding 4 (44.4%), menorrhagia 2 (22.2%), and intracranial hemorrhage (ICH) 1 (11.1%). Only 1 (11.1%) had clinical splenomegaly. Platelet count of
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Life-threatening bleeding may require transfusion support, steroids, and other immunosuppressive therapy or splenectomy. To review the clinical presentation and laboratory features of ITP at Ahmadu Bello University Teaching Hospital (ABUTH), Zaria, Nigeria. A retrospective analytic study of case notes and bone marrow (BM) records of patients diagnosed with ITP at Haematology Department, ABUTH, Zaria, from January 1, 2004, to December 31, 2012. There were nine cases (six females, three males), aged 6-20 (mean 11.11) years. The presentations were epistaxis 8 (88.9%), purpura 4 (44.4%), gum bleeding 4 (44.4%), menorrhagia 2 (22.2%), and intracranial hemorrhage (ICH) 1 (11.1%). Only 1 (11.1%) had clinical splenomegaly. Platelet count of &lt;20 × 10 /L was found in 4 (44.4%) while 6 (66.7%) had packed cell volume of &lt;25%. All the nine cases had BM megakaryocytic hyperplasia. Six patients had blood transfusion support while 7 (77.8%) patients received oral prednisolone therapy with time to cessation of bleeding of 12-16 (mean of 8) weeks. One case had spontaneous remission while another had anti-D due to relapse after steroid therapy; this resulted in transient rise in platelet counts. None had other immunosuppressive therapy or splenectomy. Six (66.7%) cases were lost to follow-up after achieving remission and one died of ICH. ITP is not common in our center though its clinical presentations are varied. However, prednisolone and blood transfusion therapy are central to the management of these patients with favorable outcome.</description><identifier>ISSN: 0300-1652</identifier><identifier>EISSN: 2229-774X</identifier><identifier>DOI: 10.4103/0300-1652.219343</identifier><identifier>PMID: 29269984</identifier><language>eng</language><publisher>Nigeria: Medknow Publications and Media Pvt. 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Thrombocytopenic purpura
title Clinical feature and management of immune thrombocytopenic purpura in a tertiary hospital in Northwest Nigeria
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