lncTCF7 is a negative prognostic factor, and knockdown of lncTCF7 inhibits migration, proliferation and tumorigenicity in glioma

Long noncoding RNAs (lncRNAs) have been shown to play critical roles in cancer. lncTCF7 (gene symbol: WSPAR) has been reported to maintain stemness in hepatocellular carcinoma (HCC) stem cells. However, little is known about the role of lncTCF7 in glioma. The aim of this study was to identify the ro...

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Bibliographic Details
Published in:Scientific reports 2017-12, Vol.7 (1), p.17456-11, Article 17456
Main Authors: Gao, Xiao, Guo, Xing, Xue, Hao, Qiu, Wei, Guo, Xiaofan, Zhang, Jinsen, Qian, Mingyu, Li, Tong, Liu, Qinglin, Shen, Jie, Deng, Lin, Li, Gang
Format: Article
Language:English
Subjects:
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Autocrine signalling
Brain tumors
Cell adhesion & migration
Cell migration
Glioma
Glioma cells
Hepatocellular carcinoma
Humanities and Social Sciences
Hypoxia
Interleukin 6
multidisciplinary
Prognosis
Science
Science (multidisciplinary)
Stem cells
Tumorigenicity
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Summary:Long noncoding RNAs (lncRNAs) have been shown to play critical roles in cancer. lncTCF7 (gene symbol: WSPAR) has been reported to maintain stemness in hepatocellular carcinoma (HCC) stem cells. However, little is known about the role of lncTCF7 in glioma. The aim of this study was to identify the role of lncTCF7 in the pathogenesis of glioma. We analysed the relationship of lncTCF7 expression with clinicopathological characteristics in glioma patients. Our results showed that lncTCF7 expression was increased in glioma tissues compared with that in normal brain tissues (P 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-17340-y