Inhibition of nuclear Wnt signalling: challenges of an elusive target for cancer therapy

• Published in: British journal of pharmacology 2017-12, Vol.174 (24), p.4589-4599
• Main Authors: Lyou, Yung, Habowski, Amber N, Chen, George T, Waterman, Marian L
• Format: Article
• Language: English
• Subjects: Animals; Antineoplastic Agents - pharmacology; Cancer; Cancer therapies; Catenin; Cell Nucleus - drug effects; Cell Nucleus - metabolism; Cell proliferation; Cell survival; Embryogenesis; Embryonic growth stage; Frizzled protein; Humans; Kinases; LEF protein; LRP5 protein; Lymphocytes T; Metabolism; Migration; Neoplasms - drug therapy; Neoplasms - metabolism; Neoplasms - pathology; Nuclei (cytology); Proteins; Review; Signal transduction; Signal Transduction - drug effects; Themed Section: Review; Transcription factors; Translocation; Wnt protein; Wnt Proteins - antagonists & inhibitors; Wnt Proteins - metabolism
• ISSN: 0007-1188; 1476-5381
• DOI: 10.1111/bph.13963

The highly conserved Wnt signalling pathway plays an important role in embryonic development and disease pathogenesis, most notably cancer. The ‘canonical’ or β‐catenin‐dependent Wnt signal initiates at the cell plasma membrane with the binding of Wnt proteins to Frizzled:LRP5/LRP6 receptor complexes and is mediated by the translocation of the transcription co‐activator protein, β‐catenin, into the nucleus. β‐Catenin then forms a complex with T‐cell factor (TCF)/lymphoid enhancer binding factor (LEF) transcription factors to regulate multiple gene programmes. These programmes play roles in cell proliferation, migration, vasculogenesis, survival and metabolism. Mutations in Wnt signalling pathway components lead to constitutively active Wnt signalling that drives aberrant expression of these programmes and development of cancer. It has been a longstanding and challenging goal to develop therapies that can interfere with the TCF/LEF–β‐catenin transcriptional complex. This review will focus on the (i) structural considerations for targeting the TCF/LEF–β‐catenin and co‐regulatory complexes in the nucleus, (ii) current molecules that directly target TCF/LEF–β‐catenin activity and (iii) ideas for targeting newly discovered components of the TCF/LEF–β‐catenin complex and/or downstream gene programmes regulated by these complexes. Linked Articles This article is part of a themed section on WNT Signalling: Mechanisms and Therapeutic Opportunities. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.24/issuetoc