Liver X receptors as potential targets for cancer therapeutics

Liver X receptors (LXRs) are important members of the nuclear receptor family that were originally determined to function in cholesterol transport and the regulation of immune responses. Synthetic LXR ligands have been developed to treat various diseases including diabetes, Alzheimer's disease...

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Bibliographic Details
Published in:Oncology letters 2017-12, Vol.14 (6), p.7676-7680
Main Authors: Ju, Xiaoli, Huang, Pan, Chen, Miao, Wang, Qiang
Format: Article
Language:English
Subjects:
Alzheimer's disease
Angiogenesis
Apoptosis
Breast cancer
cancer
cancer therapeutics
Cancer treatment
Cell cycle
Cell growth
Cell receptors
Cholesterol
clinical application
Colorectal cancer
Diabetes
Gene expression
Genetic aspects
Growth factors
Health aspects
Homeostasis
Immune response
Innovations
Kinases
Ligands
Lipids
liver X receptors
Metabolism
Metabolites
Molecular targeted therapy
Oncology
Pancreatic cancer
Prostate cancer
Proteins
Review
Rodents
Roles
Studies
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Summary:Liver X receptors (LXRs) are important members of the nuclear receptor family that were originally determined to function in cholesterol transport and the regulation of immune responses. Synthetic LXR ligands have been developed to treat various diseases including diabetes, Alzheimer's disease and atherosclerosis. Previous studies have suggested that LXRs are also involved in numerous types of cancer and are therefore potential targets for cancer therapeutics. The present review summarizes LXR ligands and their mechanisms of action, the effects of LXRs in different types of cancer and their potential applications in clinical treatment. Together, the studies discussed in the present review indicate that LXRs may be potential targets for cancer therapeutics.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2017.7259