Benefits of probiotics in preterm neonates in low-income and medium-income countries: a systematic review of randomised controlled trials

ObjectiveAlthough there is an overall reduction in underfive mortality rate, the progress in reducing neonatal mortality rate has been very slow. Over the last 20 years, preterm births have steadily increased in low-income and medium-income countries (LMICs) particularly in sub-Saharan Africa and So...

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Bibliographic Details
Published in:BMJ open 2017-12, Vol.7 (12), p.e017638-e017638
Main Authors: Deshpande, Girish, Jape, Gayatri, Rao, Shripada, Patole, Sanjay
Format: Article
Language:English
Subjects:
Africa South of the Sahara
Asia
Babies
Birth weight
Developing Countries
Enterocolitis, Necrotizing - prevention & control
Evidence-based medicine
Gastrointestinal diseases
Humans
Industrialized nations
Infant
Infant, Newborn
Infant, Premature
Low income groups
Morbidity
Mortality
Necrosis
Newborn babies
Paediatrics
Pathogens
Pediatrics
Poverty
Premature babies
Premature birth
Prevention
Probiotics
Probiotics - therapeutic use
Randomized Controlled Trials as Topic
Sepsis
Systematic review
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Summary:ObjectiveAlthough there is an overall reduction in underfive mortality rate, the progress in reducing neonatal mortality rate has been very slow. Over the last 20 years, preterm births have steadily increased in low-income and medium-income countries (LMICs) particularly in sub-Saharan Africa and South Asia. Preterm birth is associated with increased mortality and morbidity, particularly in LMICs. Based on systematic reviews of randomised controlled trials (RCTs), many neonatal units in high-income countries have adopted probiotics as standard of care for preterm neonates. We aimed to systematically review the safety and efficacy of probiotics in reducing mortality and morbidity in preterm neonates in LMICs.DesignSystematic review and meta-analysis of RCTs.Data sourcesMedline, Embase, Cochrane Central Register of Controlled Trials, Cumulative Index of Nursing and Allied Health Literature and E-abstracts from Pediatric Academic Society meetings and other paediatric and neonatal conference proceedings were searched in January 2017.Eligibility criteriaRCTs comparing probiotics versus placebo/no probiotic in preterm neonates (gestation
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2017-017638