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Gut microbiota-mediated protection against diarrheal infections
The mammalian gut microbiota is a highly abundant and diverse microbial community that resides in the gastrointestinal tract. One major benefit that the gut microbiota provides to its host is colonization resistance-the ability to prevent colonization by foreign microbes, including diarrheal pathoge...
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Published in: | Journal of travel medicine 2017-04, Vol.24 (suppl_1), p.S39-S43 |
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container_end_page | S43 |
container_issue | suppl_1 |
container_start_page | S39 |
container_title | Journal of travel medicine |
container_volume | 24 |
creator | Vogt, Stefanie L Finlay, B Brett |
description | The mammalian gut microbiota is a highly abundant and diverse microbial community that resides in the gastrointestinal tract. One major benefit that the gut microbiota provides to its host is colonization resistance-the ability to prevent colonization by foreign microbes, including diarrheal pathogens such as Clostridium difficile , Salmonella enterica serovar Typhimurium and diarrheagenic Escherichia coli .
We conducted a literature review of the effects of the gut microbiota on infection by diarrheal pathogens. We used PubMed to search for relevant articles published before July 2016, as well as incorporated data from our laboratory.
The gut microbiota provides protection from diarrheal infections both by direct inhibition of pathogens and by indirect effects on host functions. Direct effects of the microbiota on diarrheal pathogens include competing for nutrients and producing metabolites that inhibit pathogen growth or virulence. Indirect effects of the gut microbiota include promoting maintenance of the gut mucosal barrier and stimulating innate and adaptive immunity.
Human epidemiological studies and experimental infections of laboratory animals both demonstrate that antibiotic treatment can alter the gut microbial community and thereby reduce colonization resistance against diarrheal pathogens. Further research might lead to the development of next-generation probiotics that could be used to bolster colonization resistance and thus prevent travellers' diarrheal. |
doi_str_mv | 10.1093/jtm/taw086 |
format | article |
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We conducted a literature review of the effects of the gut microbiota on infection by diarrheal pathogens. We used PubMed to search for relevant articles published before July 2016, as well as incorporated data from our laboratory.
The gut microbiota provides protection from diarrheal infections both by direct inhibition of pathogens and by indirect effects on host functions. Direct effects of the microbiota on diarrheal pathogens include competing for nutrients and producing metabolites that inhibit pathogen growth or virulence. Indirect effects of the gut microbiota include promoting maintenance of the gut mucosal barrier and stimulating innate and adaptive immunity.
Human epidemiological studies and experimental infections of laboratory animals both demonstrate that antibiotic treatment can alter the gut microbial community and thereby reduce colonization resistance against diarrheal pathogens. Further research might lead to the development of next-generation probiotics that could be used to bolster colonization resistance and thus prevent travellers' diarrheal.</description><identifier>ISSN: 1195-1982</identifier><identifier>EISSN: 1708-8305</identifier><identifier>DOI: 10.1093/jtm/taw086</identifier><identifier>PMID: 28520994</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Diarrhea - microbiology ; Diarrhea - prevention & control ; Gastrointestinal Microbiome - immunology ; Humans ; Intestinal Mucosa - immunology ; Intestinal Mucosa - microbiology ; Reviews ; Travel</subject><ispartof>Journal of travel medicine, 2017-04, Vol.24 (suppl_1), p.S39-S43</ispartof><rights>International Society of Travel Medicine, 2016. Published by Oxford University Press All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com</rights><rights>International Society of Travel Medicine, 2016. Published by Oxford University Press All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-5d52cc4fc722b68c0b81ff1da2188bb53d48be52099336749f39a0e17d4408d33</citedby><cites>FETCH-LOGICAL-c378t-5d52cc4fc722b68c0b81ff1da2188bb53d48be52099336749f39a0e17d4408d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28520994$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vogt, Stefanie L</creatorcontrib><creatorcontrib>Finlay, B Brett</creatorcontrib><title>Gut microbiota-mediated protection against diarrheal infections</title><title>Journal of travel medicine</title><addtitle>J Travel Med</addtitle><description>The mammalian gut microbiota is a highly abundant and diverse microbial community that resides in the gastrointestinal tract. One major benefit that the gut microbiota provides to its host is colonization resistance-the ability to prevent colonization by foreign microbes, including diarrheal pathogens such as Clostridium difficile , Salmonella enterica serovar Typhimurium and diarrheagenic Escherichia coli .
We conducted a literature review of the effects of the gut microbiota on infection by diarrheal pathogens. We used PubMed to search for relevant articles published before July 2016, as well as incorporated data from our laboratory.
The gut microbiota provides protection from diarrheal infections both by direct inhibition of pathogens and by indirect effects on host functions. Direct effects of the microbiota on diarrheal pathogens include competing for nutrients and producing metabolites that inhibit pathogen growth or virulence. Indirect effects of the gut microbiota include promoting maintenance of the gut mucosal barrier and stimulating innate and adaptive immunity.
Human epidemiological studies and experimental infections of laboratory animals both demonstrate that antibiotic treatment can alter the gut microbial community and thereby reduce colonization resistance against diarrheal pathogens. Further research might lead to the development of next-generation probiotics that could be used to bolster colonization resistance and thus prevent travellers' diarrheal.</description><subject>Diarrhea - microbiology</subject><subject>Diarrhea - prevention & control</subject><subject>Gastrointestinal Microbiome - immunology</subject><subject>Humans</subject><subject>Intestinal Mucosa - immunology</subject><subject>Intestinal Mucosa - microbiology</subject><subject>Reviews</subject><subject>Travel</subject><issn>1195-1982</issn><issn>1708-8305</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpVkF1LwzAYhYMobk5v_AHSSxHq3nx0TW4UGX7BwBu9DmmabhltM5NU8d_b2Tn06n3hHM45PAidY7jGIOh0HZtpVJ_AZwdojHPgKaeQHfY_FlmKBScjdBLCGgAIJ-QYjQjPCAjBxuj2sYtJY7V3hXVRpY0prYqmTDbeRaOjdW2ilsq2ISa94v3KqDqxbTVo4RQdVaoO5mx3J-jt4f51_pQuXh6f53eLVNOcxzQrM6I1q3ROSDHjGgqOqwqXimDOiyKjJeOF-RlF6SxnoqJCgcF5yRjwktIJuhlyN13Rb9SmjV7VcuNto_yXdMrK_0prV3LpPmSWU8wY6wMudwHevXcmRNnYoE1dq9a4LkgsADgDKrZdV4O1pxKCN9W-BoPcEpc9cTkQ780Xf4ftrb-I6Tfx-37D</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Vogt, Stefanie L</creator><creator>Finlay, B Brett</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170401</creationdate><title>Gut microbiota-mediated protection against diarrheal infections</title><author>Vogt, Stefanie L ; Finlay, B Brett</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-5d52cc4fc722b68c0b81ff1da2188bb53d48be52099336749f39a0e17d4408d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Diarrhea - microbiology</topic><topic>Diarrhea - prevention & control</topic><topic>Gastrointestinal Microbiome - immunology</topic><topic>Humans</topic><topic>Intestinal Mucosa - immunology</topic><topic>Intestinal Mucosa - microbiology</topic><topic>Reviews</topic><topic>Travel</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vogt, Stefanie L</creatorcontrib><creatorcontrib>Finlay, B Brett</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of travel medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vogt, Stefanie L</au><au>Finlay, B Brett</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gut microbiota-mediated protection against diarrheal infections</atitle><jtitle>Journal of travel medicine</jtitle><addtitle>J Travel Med</addtitle><date>2017-04-01</date><risdate>2017</risdate><volume>24</volume><issue>suppl_1</issue><spage>S39</spage><epage>S43</epage><pages>S39-S43</pages><issn>1195-1982</issn><eissn>1708-8305</eissn><abstract>The mammalian gut microbiota is a highly abundant and diverse microbial community that resides in the gastrointestinal tract. One major benefit that the gut microbiota provides to its host is colonization resistance-the ability to prevent colonization by foreign microbes, including diarrheal pathogens such as Clostridium difficile , Salmonella enterica serovar Typhimurium and diarrheagenic Escherichia coli .
We conducted a literature review of the effects of the gut microbiota on infection by diarrheal pathogens. We used PubMed to search for relevant articles published before July 2016, as well as incorporated data from our laboratory.
The gut microbiota provides protection from diarrheal infections both by direct inhibition of pathogens and by indirect effects on host functions. Direct effects of the microbiota on diarrheal pathogens include competing for nutrients and producing metabolites that inhibit pathogen growth or virulence. Indirect effects of the gut microbiota include promoting maintenance of the gut mucosal barrier and stimulating innate and adaptive immunity.
Human epidemiological studies and experimental infections of laboratory animals both demonstrate that antibiotic treatment can alter the gut microbial community and thereby reduce colonization resistance against diarrheal pathogens. Further research might lead to the development of next-generation probiotics that could be used to bolster colonization resistance and thus prevent travellers' diarrheal.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>28520994</pmid><doi>10.1093/jtm/taw086</doi><oa>free_for_read</oa></addata></record> |
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issn | 1195-1982 1708-8305 |
language | eng |
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source | Oxford Journals Online |
subjects | Diarrhea - microbiology Diarrhea - prevention & control Gastrointestinal Microbiome - immunology Humans Intestinal Mucosa - immunology Intestinal Mucosa - microbiology Reviews Travel |
title | Gut microbiota-mediated protection against diarrheal infections |
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