Loading…

Gut microbiota-mediated protection against diarrheal infections

The mammalian gut microbiota is a highly abundant and diverse microbial community that resides in the gastrointestinal tract. One major benefit that the gut microbiota provides to its host is colonization resistance-the ability to prevent colonization by foreign microbes, including diarrheal pathoge...

Full description

Saved in:
Bibliographic Details
Published in:Journal of travel medicine 2017-04, Vol.24 (suppl_1), p.S39-S43
Main Authors: Vogt, Stefanie L, Finlay, B Brett
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c378t-5d52cc4fc722b68c0b81ff1da2188bb53d48be52099336749f39a0e17d4408d33
cites cdi_FETCH-LOGICAL-c378t-5d52cc4fc722b68c0b81ff1da2188bb53d48be52099336749f39a0e17d4408d33
container_end_page S43
container_issue suppl_1
container_start_page S39
container_title Journal of travel medicine
container_volume 24
creator Vogt, Stefanie L
Finlay, B Brett
description The mammalian gut microbiota is a highly abundant and diverse microbial community that resides in the gastrointestinal tract. One major benefit that the gut microbiota provides to its host is colonization resistance-the ability to prevent colonization by foreign microbes, including diarrheal pathogens such as Clostridium difficile , Salmonella enterica serovar Typhimurium and diarrheagenic Escherichia coli . We conducted a literature review of the effects of the gut microbiota on infection by diarrheal pathogens. We used PubMed to search for relevant articles published before July 2016, as well as incorporated data from our laboratory. The gut microbiota provides protection from diarrheal infections both by direct inhibition of pathogens and by indirect effects on host functions. Direct effects of the microbiota on diarrheal pathogens include competing for nutrients and producing metabolites that inhibit pathogen growth or virulence. Indirect effects of the gut microbiota include promoting maintenance of the gut mucosal barrier and stimulating innate and adaptive immunity. Human epidemiological studies and experimental infections of laboratory animals both demonstrate that antibiotic treatment can alter the gut microbial community and thereby reduce colonization resistance against diarrheal pathogens. Further research might lead to the development of next-generation probiotics that could be used to bolster colonization resistance and thus prevent travellers' diarrheal.
doi_str_mv 10.1093/jtm/taw086
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5731444</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1900840393</sourcerecordid><originalsourceid>FETCH-LOGICAL-c378t-5d52cc4fc722b68c0b81ff1da2188bb53d48be52099336749f39a0e17d4408d33</originalsourceid><addsrcrecordid>eNpVkF1LwzAYhYMobk5v_AHSSxHq3nx0TW4UGX7BwBu9DmmabhltM5NU8d_b2Tn06n3hHM45PAidY7jGIOh0HZtpVJ_AZwdojHPgKaeQHfY_FlmKBScjdBLCGgAIJ-QYjQjPCAjBxuj2sYtJY7V3hXVRpY0prYqmTDbeRaOjdW2ilsq2ISa94v3KqDqxbTVo4RQdVaoO5mx3J-jt4f51_pQuXh6f53eLVNOcxzQrM6I1q3ROSDHjGgqOqwqXimDOiyKjJeOF-RlF6SxnoqJCgcF5yRjwktIJuhlyN13Rb9SmjV7VcuNto_yXdMrK_0prV3LpPmSWU8wY6wMudwHevXcmRNnYoE1dq9a4LkgsADgDKrZdV4O1pxKCN9W-BoPcEpc9cTkQ780Xf4ftrb-I6Tfx-37D</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1900840393</pqid></control><display><type>article</type><title>Gut microbiota-mediated protection against diarrheal infections</title><source>Oxford Journals Online</source><creator>Vogt, Stefanie L ; Finlay, B Brett</creator><creatorcontrib>Vogt, Stefanie L ; Finlay, B Brett</creatorcontrib><description>The mammalian gut microbiota is a highly abundant and diverse microbial community that resides in the gastrointestinal tract. One major benefit that the gut microbiota provides to its host is colonization resistance-the ability to prevent colonization by foreign microbes, including diarrheal pathogens such as Clostridium difficile , Salmonella enterica serovar Typhimurium and diarrheagenic Escherichia coli . We conducted a literature review of the effects of the gut microbiota on infection by diarrheal pathogens. We used PubMed to search for relevant articles published before July 2016, as well as incorporated data from our laboratory. The gut microbiota provides protection from diarrheal infections both by direct inhibition of pathogens and by indirect effects on host functions. Direct effects of the microbiota on diarrheal pathogens include competing for nutrients and producing metabolites that inhibit pathogen growth or virulence. Indirect effects of the gut microbiota include promoting maintenance of the gut mucosal barrier and stimulating innate and adaptive immunity. Human epidemiological studies and experimental infections of laboratory animals both demonstrate that antibiotic treatment can alter the gut microbial community and thereby reduce colonization resistance against diarrheal pathogens. Further research might lead to the development of next-generation probiotics that could be used to bolster colonization resistance and thus prevent travellers' diarrheal.</description><identifier>ISSN: 1195-1982</identifier><identifier>EISSN: 1708-8305</identifier><identifier>DOI: 10.1093/jtm/taw086</identifier><identifier>PMID: 28520994</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Diarrhea - microbiology ; Diarrhea - prevention &amp; control ; Gastrointestinal Microbiome - immunology ; Humans ; Intestinal Mucosa - immunology ; Intestinal Mucosa - microbiology ; Reviews ; Travel</subject><ispartof>Journal of travel medicine, 2017-04, Vol.24 (suppl_1), p.S39-S43</ispartof><rights>International Society of Travel Medicine, 2016. Published by Oxford University Press All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com</rights><rights>International Society of Travel Medicine, 2016. Published by Oxford University Press All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-5d52cc4fc722b68c0b81ff1da2188bb53d48be52099336749f39a0e17d4408d33</citedby><cites>FETCH-LOGICAL-c378t-5d52cc4fc722b68c0b81ff1da2188bb53d48be52099336749f39a0e17d4408d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28520994$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vogt, Stefanie L</creatorcontrib><creatorcontrib>Finlay, B Brett</creatorcontrib><title>Gut microbiota-mediated protection against diarrheal infections</title><title>Journal of travel medicine</title><addtitle>J Travel Med</addtitle><description>The mammalian gut microbiota is a highly abundant and diverse microbial community that resides in the gastrointestinal tract. One major benefit that the gut microbiota provides to its host is colonization resistance-the ability to prevent colonization by foreign microbes, including diarrheal pathogens such as Clostridium difficile , Salmonella enterica serovar Typhimurium and diarrheagenic Escherichia coli . We conducted a literature review of the effects of the gut microbiota on infection by diarrheal pathogens. We used PubMed to search for relevant articles published before July 2016, as well as incorporated data from our laboratory. The gut microbiota provides protection from diarrheal infections both by direct inhibition of pathogens and by indirect effects on host functions. Direct effects of the microbiota on diarrheal pathogens include competing for nutrients and producing metabolites that inhibit pathogen growth or virulence. Indirect effects of the gut microbiota include promoting maintenance of the gut mucosal barrier and stimulating innate and adaptive immunity. Human epidemiological studies and experimental infections of laboratory animals both demonstrate that antibiotic treatment can alter the gut microbial community and thereby reduce colonization resistance against diarrheal pathogens. Further research might lead to the development of next-generation probiotics that could be used to bolster colonization resistance and thus prevent travellers' diarrheal.</description><subject>Diarrhea - microbiology</subject><subject>Diarrhea - prevention &amp; control</subject><subject>Gastrointestinal Microbiome - immunology</subject><subject>Humans</subject><subject>Intestinal Mucosa - immunology</subject><subject>Intestinal Mucosa - microbiology</subject><subject>Reviews</subject><subject>Travel</subject><issn>1195-1982</issn><issn>1708-8305</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpVkF1LwzAYhYMobk5v_AHSSxHq3nx0TW4UGX7BwBu9DmmabhltM5NU8d_b2Tn06n3hHM45PAidY7jGIOh0HZtpVJ_AZwdojHPgKaeQHfY_FlmKBScjdBLCGgAIJ-QYjQjPCAjBxuj2sYtJY7V3hXVRpY0prYqmTDbeRaOjdW2ilsq2ISa94v3KqDqxbTVo4RQdVaoO5mx3J-jt4f51_pQuXh6f53eLVNOcxzQrM6I1q3ROSDHjGgqOqwqXimDOiyKjJeOF-RlF6SxnoqJCgcF5yRjwktIJuhlyN13Rb9SmjV7VcuNto_yXdMrK_0prV3LpPmSWU8wY6wMudwHevXcmRNnYoE1dq9a4LkgsADgDKrZdV4O1pxKCN9W-BoPcEpc9cTkQ780Xf4ftrb-I6Tfx-37D</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Vogt, Stefanie L</creator><creator>Finlay, B Brett</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170401</creationdate><title>Gut microbiota-mediated protection against diarrheal infections</title><author>Vogt, Stefanie L ; Finlay, B Brett</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-5d52cc4fc722b68c0b81ff1da2188bb53d48be52099336749f39a0e17d4408d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Diarrhea - microbiology</topic><topic>Diarrhea - prevention &amp; control</topic><topic>Gastrointestinal Microbiome - immunology</topic><topic>Humans</topic><topic>Intestinal Mucosa - immunology</topic><topic>Intestinal Mucosa - microbiology</topic><topic>Reviews</topic><topic>Travel</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vogt, Stefanie L</creatorcontrib><creatorcontrib>Finlay, B Brett</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of travel medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vogt, Stefanie L</au><au>Finlay, B Brett</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gut microbiota-mediated protection against diarrheal infections</atitle><jtitle>Journal of travel medicine</jtitle><addtitle>J Travel Med</addtitle><date>2017-04-01</date><risdate>2017</risdate><volume>24</volume><issue>suppl_1</issue><spage>S39</spage><epage>S43</epage><pages>S39-S43</pages><issn>1195-1982</issn><eissn>1708-8305</eissn><abstract>The mammalian gut microbiota is a highly abundant and diverse microbial community that resides in the gastrointestinal tract. One major benefit that the gut microbiota provides to its host is colonization resistance-the ability to prevent colonization by foreign microbes, including diarrheal pathogens such as Clostridium difficile , Salmonella enterica serovar Typhimurium and diarrheagenic Escherichia coli . We conducted a literature review of the effects of the gut microbiota on infection by diarrheal pathogens. We used PubMed to search for relevant articles published before July 2016, as well as incorporated data from our laboratory. The gut microbiota provides protection from diarrheal infections both by direct inhibition of pathogens and by indirect effects on host functions. Direct effects of the microbiota on diarrheal pathogens include competing for nutrients and producing metabolites that inhibit pathogen growth or virulence. Indirect effects of the gut microbiota include promoting maintenance of the gut mucosal barrier and stimulating innate and adaptive immunity. Human epidemiological studies and experimental infections of laboratory animals both demonstrate that antibiotic treatment can alter the gut microbial community and thereby reduce colonization resistance against diarrheal pathogens. Further research might lead to the development of next-generation probiotics that could be used to bolster colonization resistance and thus prevent travellers' diarrheal.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>28520994</pmid><doi>10.1093/jtm/taw086</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1195-1982
ispartof Journal of travel medicine, 2017-04, Vol.24 (suppl_1), p.S39-S43
issn 1195-1982
1708-8305
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5731444
source Oxford Journals Online
subjects Diarrhea - microbiology
Diarrhea - prevention & control
Gastrointestinal Microbiome - immunology
Humans
Intestinal Mucosa - immunology
Intestinal Mucosa - microbiology
Reviews
Travel
title Gut microbiota-mediated protection against diarrheal infections
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T03%3A38%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gut%20microbiota-mediated%20protection%20against%20diarrheal%20infections&rft.jtitle=Journal%20of%20travel%20medicine&rft.au=Vogt,%20Stefanie%20L&rft.date=2017-04-01&rft.volume=24&rft.issue=suppl_1&rft.spage=S39&rft.epage=S43&rft.pages=S39-S43&rft.issn=1195-1982&rft.eissn=1708-8305&rft_id=info:doi/10.1093/jtm/taw086&rft_dat=%3Cproquest_pubme%3E1900840393%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c378t-5d52cc4fc722b68c0b81ff1da2188bb53d48be52099336749f39a0e17d4408d33%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1900840393&rft_id=info:pmid/28520994&rfr_iscdi=true