Brain network alterations in the inflammatory soup animal model of migraine

Highlights • This manuscript describes, for the first time, brain network alterations in the inflammatory soup model of migraine. • We found that several brain networks are altered in the model compared to controls and that some of those alterations are similar to those observed in patients sufferin...

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Bibliographic Details
Published in:Brain research 2017-04, Vol.1660, p.36-46
Main Authors: Becerra, Lino, Bishop, James, Barmettler, Gabi, Kainz, Vanessa, Burstein, Rami, Borsook, David
Format: Article
Language:English
Subjects:
Animals
Brain - diagnostic imaging
Brain - physiopathology
Brain Mapping
Disease Models, Animal
fMRI
Hot Temperature
Inflammatory soup
Magnetic Resonance Imaging
Male
Migraine
Migraine Disorders - diagnostic imaging
Migraine Disorders - physiopathology
Neural Pathways - diagnostic imaging
Neural Pathways - physiopathology
Neurology
Nociceptive Pain - diagnostic imaging
Nociceptive Pain - physiopathology
Physical Stimulation
Rat
Rats, Sprague-Dawley
Rest
Resting state networks
Touch Perception - physiology
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Summary:Highlights • This manuscript describes, for the first time, brain network alterations in the inflammatory soup model of migraine. • We found that several brain networks are altered in the model compared to controls and that some of those alterations are similar to those observed in patients suffering of migraine. • We also further provide experimental evidence that the model induces alterations in brain responses to mechanical stimulations producing an enhanced fMRI activity as compared to controls.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2017.02.001