Antidepressant-Like Effect of Selected Egyptian Cultivars of Flaxseed Oil on a Rodent Model of Postpartum Depression

Flaxseed (Linum usitatissimum L.) is a multipurpose crop with health promoting potential. This study was undertaken to investigate the fatty acid profile and yield of fixed oil of six Egyptian flaxseed cultivars. The selected cultivars with the highest content of polyunsaturated fatty acids (PUFAs)...

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Published in:Evidence-based complementary and alternative medicine 2017-01, Vol.2017 (2017), p.1-15
Main Authors: Abdel Sattar, Essam, Choucry, Mouchira A., Ezzat, Shahira M., El Gayed, Sabah H., Abdel Wahab, Samia, Ali, Zeinab Y., El Sayed, Abeer Mohamed, El Tanbouly, Nebal, El Senousy, Amira Safwat
Format: Article
Language:English
Subjects:
Amine oxidase (flavin-containing)
Antidepressants
Anxiety
Biochemical analysis
Computer simulation
Corticosterone
Cultivars
Cytokines
Fluoxetine
Hippocampus
Inflammation
Kinases
Linaceae
Linum usitatissimum
Locomotor activity
Mental depression
Monoamine oxidase
Oil
Oilseeds
Open-field behavior
Polyunsaturated fatty acids
Postpartum
Postpartum depression
Pregnancy
Rats
Redox properties
Tumor necrosis factor-TNF
Unsaturated fatty acids
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Summary:Flaxseed (Linum usitatissimum L.) is a multipurpose crop with health promoting potential. This study was undertaken to investigate the fatty acid profile and yield of fixed oil of six Egyptian flaxseed cultivars. The selected cultivars with the highest content of polyunsaturated fatty acids (PUFAs) (G9 and G10) were assessed for their antidepressant-like effect in rat model of postpartum depression (PPD) induced by hormone-simulated pregnancy followed by hormone withdrawal and compared to fluoxetine. As compared to control group, administration of G9 and G10 (270 mg/kg/day, p.o) for two weeks during the postpartum period can alleviate anxiety and depressive-like behaviors and biochemical changes in PPD-induced rats. This was confirmed by evaluation of anxiety-like behaviors (elevated plus maze, open field test, and forced swim test tests), in addition to biochemical analysis (brain monoamine oxidase-A, corticosterone level, proinflammatory cytokines, and hippocampal redox state). In conclusion, flaxseed oil of Egyptian cultivars G9 and G10 exhibited significant antidepressant-like effect in rat model of PPD without affecting locomotor activity. At the treatment doses, the antidepressant-like activity of Giza 9 oil is comparable to fluoxetine.
ISSN:1741-427X
1741-4288
DOI:10.1155/2017/6405789