Model-based Bayesian signal extraction algorithm for peripheral nerves

• Published in: Journal of neural engineering 2017-10, Vol.14 (5), p.056009-056009
• Main Authors: Eggers, Thomas E, Dweiri, Yazan M, McCallum, Grant A, Durand, Dominique M
• Format: Article
• Language: English
• Subjects: Algorithms; Animals; Bayes Theorem; Dogs; Electromyography - methods; Humans; Models, Neurological; Muscle, Skeletal - innervation; Muscle, Skeletal - physiology; nerve cuff electrode; neural signal processing; peripheral nerve interface; Peripheral Nerves - physiology; Sciatic Nerve - physiology
• ISSN: 1741-2560; 1741-2552
• DOI: 10.1088/1741-2552/aa7d94

Objective. Multi-channel cuff electrodes have recently been investigated for extracting fascicular-level motor commands from mixed neural recordings. Such signals could provide volitional, intuitive control over a robotic prosthesis for amputee patients. Recent work has demonstrated success in extracting these signals in acute and chronic preparations using spatial filtering techniques. These extracted signals, however, had low signal-to-noise ratios and thus limited their utility to binary classification. In this work a new algorithm is proposed which combines previous source localization approaches to create a model based method which operates in real time. Approach. To validate this algorithm, a saline benchtop setup was created to allow the precise placement of artificial sources within a cuff and interference sources outside the cuff. The artificial source was taken from five seconds of chronic neural activity to replicate realistic recordings. The proposed algorithm, hybrid Bayesian signal extraction (HBSE), is then compared to previous algorithms, beamforming and a Bayesian spatial filtering method, on this test data. An example chronic neural recording is also analyzed with all three algorithms. Main results. The proposed algorithm improved the signal to noise and signal to interference ratio of extracted test signals two to three fold, as well as increased the correlation coefficient between the original and recovered signals by 10-20%. These improvements translated to the chronic recording example and increased the calculated bit rate between the recovered signals and the recorded motor activity. Significance. HBSE significantly outperforms previous algorithms in extracting realistic neural signals, even in the presence of external noise sources. These results demonstrate the feasibility of extracting dynamic motor signals from a multi-fascicled intact nerve trunk, which in turn could extract motor command signals from an amputee for the end goal of controlling a prosthetic limb.