Identification of long non-coding RNAs in the immature and mature rat anterior pituitary

Many long non-coding RNAs (lncRNAs) have been identified in several types of human pituitary adenomas and normal anterior pituitary, some of which are involved in the pathogenesis of pituitary adenomas. However, a systematic analysis of lncRNAs expressed at different developmental stages of normal p...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2017-12, Vol.7 (1), p.17780-9, Article 17780
Main Authors: Han, Dong-Xu, Sun, Xu-Lei, Fu, Yao, Wang, Chang-Jiang, Liu, Jian-Bo, Jiang, Hao, Gao, Yan, Chen, Cheng-Zhen, Yuan, Bao, Zhang, Jia-Bao
Format: Article
Language:English
Subjects:
45/91
631/136
631/80
Animals
Developmental stages
Follicle-stimulating hormone
Gene Expression Profiling - methods
Gene Library
Gene Regulatory Networks - genetics
Humanities and Social Sciences
multidisciplinary
Pituitary (anterior)
Pituitary Gland - metabolism
Pituitary Neoplasms - genetics
Rats
Rats, Wistar
RNA, Long Noncoding - genetics
Science
Science (multidisciplinary)
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Many long non-coding RNAs (lncRNAs) have been identified in several types of human pituitary adenomas and normal anterior pituitary, some of which are involved in the pathogenesis of pituitary adenomas. However, a systematic analysis of lncRNAs expressed at different developmental stages of normal pituitary, particularly in rats, has not been performed. Therefore, we contrasted two cDNA libraries of immature (D15) and mature (D120) anterior pituitary in rat that were sequenced on an Illumina HiSeq Xten platform, and a total of 29,568,806,352 clean reads were identified. Notably, 7039 lncRNA transcripts corresponded to 4442 lncRNA genes, and 1181 lncRNA transcripts were significantly differentially expressed in D15 and D120. In addition, 6839 protein-coding genes (
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-17996-6