Incremental effects of antihypertensive drugs: instrumental variable analysis

To assess the incremental effects of adding extra antihypertensive drugs from a new class to a patient's regimen. Instrumental variable analysis of data from SPRINT (Systolic Blood Pressure Intervention Trial). To account for confounding by indication-when treatments seem less effective if they...

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Bibliographic Details
Published in:BMJ (Online) 2017-12, Vol.359, p.j5542-j5542
Main Authors: Markovitz, Adam A, Mack, Jacob A, Nallamothu, Brahmajee K, Ayanian, John Z, Ryan, Andrew M
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Antihypertensive Agents - administration & dosage
Antihypertensive Agents - adverse effects
Antihypertensive Agents - classification
Antihypertensive Agents - pharmacology
Blood Pressure - drug effects
Cardiovascular Diseases - drug therapy
Female
Humans
Hypertension - complications
Hypertension - drug therapy
Hypertension - epidemiology
Hypertension - physiopathology
Male
Middle Aged
Outcome Assessment (Health Care)
Randomized Controlled Trials as Topic
Risk Factors
Systole - drug effects
Treatment Outcome
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Summary:To assess the incremental effects of adding extra antihypertensive drugs from a new class to a patient's regimen. Instrumental variable analysis of data from SPRINT (Systolic Blood Pressure Intervention Trial). To account for confounding by indication-when treatments seem less effective if they are administered to sicker patients-randomization status was used as the instrumental variable. Patients' randomization status was either intensive (systolic blood pressure target
ISSN:0959-8138
1756-1833
DOI:10.1136/bmj.j5542