Evaluation of rectum and bladder dose accumulation from external beam radiotherapy and brachytherapy for cervical cancer using two different deformable image registration techniques

• Published in: Journal of radiation research 2017-09, Vol.58 (5), p.720-728
• Main Authors: Kadoya, Noriyuki, Miyasaka, YuYa, Yamamoto, Takaya, Kuroda, Yoshihiro, Ito, Kengo, Chiba, Mizuki, Nakajima, Yujiro, Takahashi, Noriyoshi, Kubozono, Masaki, Umezawa, Rei, Dobashi, Suguru, Takeda, Ken, Jingu, Keiichi
• Format: Article
• Language: English
• Subjects: Apoptosis - radiation effects; Brachytherapy; Dose-Response Relationship, Radiation; Female; Hardness; Humans; Oncology; Photons; Radiographic Image Interpretation, Computer-Assisted; Rectum - radiation effects; Urinary Bladder - radiation effects; Uterine Cervical Neoplasms - radiotherapy
• ISSN: 0449-3060; 1349-9157
• DOI: 10.1093/jrr/rrx028

ABSTRACT We evaluated dose–volume histogram (DVH) parameters based on deformable image registration (DIR) between brachytherapy (BT) and external beam radiotherapy (EBRT) that included a center-shielded (CS) plan. Eleven cervical cancer patients were treated with BT, and their pelvic and CS EBRT were studied. Planning CT images for EBRT and BT (except for the first BT, used as the reference image) were deformed with DIR to reference image. We used two DIR parameter settings: intensity-based and hybrid. Mean Dice similarity coefficients (DSCs) comparing EBRT with the reference for the uterus, rectum and bladder were 0.81, 0.77 and 0.83, respectively, for hybrid DIR and 0.47, 0.37 and 0.42, respectively, for intensity-based DIR (P