Increased Risk of the APOB rs11279109 Polymorphism for CHD among the Kuwaiti Population

Background. Coronary heart disease (CHD) is among the leading causes of death in Kuwait. This case-control study investigated the genetic association of APOB rs11279109 with CHD in Kuwaitis. Methods. The polymorphism was genotyped in 734 Kuwaiti samples by direct amplification. Statistical analysis...

Full description

Saved in:
Bibliographic Details
Published in:Disease markers 2017-01, Vol.2017 (2017), p.1-8
Main Authors: Al-Rashdan, Ibrahim, Al-Serri, Ahmad, Ismael, Fatma G., al-Bustan, Suzanne A.
Format: Article
Language:English
Subjects:
Apolipoprotein B-100 - genetics
Apolipoproteins
Body mass
Cardiovascular disease
Cardiovascular diseases
Coronary artery disease
Coronary Disease - genetics
Coronary heart disease
Diagnosis
Female
Genetic analysis
Genetic aspects
Genetic markers
Genotype & phenotype
Genotypes
Health aspects
Health risk assessment
Heart diseases
Humans
Hypercholesterolemia
Kuwait
Low density lipoprotein
Male
Mathematical models
Middle Aged
Minority & ethnic groups
Molecular modelling
Oxidation
Polymorphism
Polymorphism, Single Nucleotide
Population (statistical)
Risk
Risk factors
Smoking
Statistical analysis
Statistical methods
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c461t-8a58fc945d84f4717ec1174592a84d0ac7c0102e80f02511de640db11599908f3
cites cdi_FETCH-LOGICAL-c461t-8a58fc945d84f4717ec1174592a84d0ac7c0102e80f02511de640db11599908f3
container_end_page 8
container_issue 2017
container_start_page 1
container_title Disease markers
container_volume 2017
creator Al-Rashdan, Ibrahim
Al-Serri, Ahmad
Ismael, Fatma G.
al-Bustan, Suzanne A.
description Background. Coronary heart disease (CHD) is among the leading causes of death in Kuwait. This case-control study investigated the genetic association of APOB rs11279109 with CHD in Kuwaitis. Methods. The polymorphism was genotyped in 734 Kuwaiti samples by direct amplification. Statistical analysis with genetic modeling was used to assess its association with CHD. Results. A statistically significant association (P
doi_str_mv 10.1155/2017/6963437
format article
fullrecord <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5737435</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A550015063</galeid><sourcerecordid>A550015063</sourcerecordid><originalsourceid>FETCH-LOGICAL-c461t-8a58fc945d84f4717ec1174592a84d0ac7c0102e80f02511de640db11599908f3</originalsourceid><addsrcrecordid>eNqN0U1v1DAQBmALgehSuHFGkbggQeiMY8fxpdKyfLSiUisE4mi5jr3rksSLnVD13-OwSwucOPngR69n_BLyFOE1IudHFFAc1bKuWCXukQU2gpdNXcF9sgAqmhIogwPyKKUrAKSSyYfkgMqqphz5gnw9HUy0Otm2-OTTtyK4YtzYYnlx_qaICZEKiSCLi9Dd9CFuNz71hQuxWJ28LXQfhvUv_nG61n70mW2nTo8-DI_JA6e7ZJ_sz0Py5f27z6uT8uz8w-lqeVYaVuNYNpo3zkjG24Y5JlBYgygYl1Q3rAVthAEEahtwkAfG1tYM2su8uJQSGlcdkuNd7na67G1r7DBG3alt9L2ONypor_6-GfxGrcMPxUUlWMVzwIt9QAzfJ5tG1ftkbNfpwYYpKZzfmTFk-vwfehWmOOT1VC4B8sfnDu7UWndW-cGF_K6ZQ9WS89wBh3pWr3bKxJBStO52ZAQ19zpHCrXvNfNnf655i38XmcHLHdj4odXX_j_jbDbW6TuNnLI83k8yea_7</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2010875343</pqid></control><display><type>article</type><title>Increased Risk of the APOB rs11279109 Polymorphism for CHD among the Kuwaiti Population</title><source>Wiley Online Library Open Access</source><creator>Al-Rashdan, Ibrahim ; Al-Serri, Ahmad ; Ismael, Fatma G. ; al-Bustan, Suzanne A.</creator><contributor>Palla, Roberta ; Roberta Palla</contributor><creatorcontrib>Al-Rashdan, Ibrahim ; Al-Serri, Ahmad ; Ismael, Fatma G. ; al-Bustan, Suzanne A. ; Palla, Roberta ; Roberta Palla</creatorcontrib><description>Background. Coronary heart disease (CHD) is among the leading causes of death in Kuwait. This case-control study investigated the genetic association of APOB rs11279109 with CHD in Kuwaitis. Methods. The polymorphism was genotyped in 734 Kuwaiti samples by direct amplification. Statistical analysis with genetic modeling was used to assess its association with CHD. Results. A statistically significant association (P&lt;0.001) between the rs11279109 DD genotype (OR: 2.43, CI: 1.34–4.41) with CHD was observed. A codominant genetic model revealed a 2.69 risk increase (CI: 1.57–4.61) for the DD genotype (P=0.009) independent of age, sex, BMI, smoking, hypercholesterolemia, and ethnicity suggesting APOB rs11279109 as an indicator for the increased risk of CHD. Conclusion. The DD genotype may explain molecular mechanisms that underline increased LDL oxidation leading to arthrosclerosis. The findings emphasize the need to identify genetic markers specific to the CHD patient ethnic group in order to improve prognosis and help in early diagnosis and prevention.</description><identifier>ISSN: 0278-0240</identifier><identifier>EISSN: 1875-8630</identifier><identifier>DOI: 10.1155/2017/6963437</identifier><identifier>PMID: 29362515</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Apolipoprotein B-100 - genetics ; Apolipoproteins ; Body mass ; Cardiovascular disease ; Cardiovascular diseases ; Coronary artery disease ; Coronary Disease - genetics ; Coronary heart disease ; Diagnosis ; Female ; Genetic analysis ; Genetic aspects ; Genetic markers ; Genotype &amp; phenotype ; Genotypes ; Health aspects ; Health risk assessment ; Heart diseases ; Humans ; Hypercholesterolemia ; Kuwait ; Low density lipoprotein ; Male ; Mathematical models ; Middle Aged ; Minority &amp; ethnic groups ; Molecular modelling ; Oxidation ; Polymorphism ; Polymorphism, Single Nucleotide ; Population (statistical) ; Risk ; Risk factors ; Smoking ; Statistical analysis ; Statistical methods</subject><ispartof>Disease markers, 2017-01, Vol.2017 (2017), p.1-8</ispartof><rights>Copyright © 2017 Suzanne A. Al-Bustan et al.</rights><rights>COPYRIGHT 2017 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2017 Suzanne A. Al-Bustan et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2017 Suzanne A. Al-Bustan et al. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-8a58fc945d84f4717ec1174592a84d0ac7c0102e80f02511de640db11599908f3</citedby><cites>FETCH-LOGICAL-c461t-8a58fc945d84f4717ec1174592a84d0ac7c0102e80f02511de640db11599908f3</cites><orcidid>0000-0002-1260-4632</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29362515$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Palla, Roberta</contributor><contributor>Roberta Palla</contributor><creatorcontrib>Al-Rashdan, Ibrahim</creatorcontrib><creatorcontrib>Al-Serri, Ahmad</creatorcontrib><creatorcontrib>Ismael, Fatma G.</creatorcontrib><creatorcontrib>al-Bustan, Suzanne A.</creatorcontrib><title>Increased Risk of the APOB rs11279109 Polymorphism for CHD among the Kuwaiti Population</title><title>Disease markers</title><addtitle>Dis Markers</addtitle><description>Background. Coronary heart disease (CHD) is among the leading causes of death in Kuwait. This case-control study investigated the genetic association of APOB rs11279109 with CHD in Kuwaitis. Methods. The polymorphism was genotyped in 734 Kuwaiti samples by direct amplification. Statistical analysis with genetic modeling was used to assess its association with CHD. Results. A statistically significant association (P&lt;0.001) between the rs11279109 DD genotype (OR: 2.43, CI: 1.34–4.41) with CHD was observed. A codominant genetic model revealed a 2.69 risk increase (CI: 1.57–4.61) for the DD genotype (P=0.009) independent of age, sex, BMI, smoking, hypercholesterolemia, and ethnicity suggesting APOB rs11279109 as an indicator for the increased risk of CHD. Conclusion. The DD genotype may explain molecular mechanisms that underline increased LDL oxidation leading to arthrosclerosis. The findings emphasize the need to identify genetic markers specific to the CHD patient ethnic group in order to improve prognosis and help in early diagnosis and prevention.</description><subject>Apolipoprotein B-100 - genetics</subject><subject>Apolipoproteins</subject><subject>Body mass</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Coronary artery disease</subject><subject>Coronary Disease - genetics</subject><subject>Coronary heart disease</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Genetic analysis</subject><subject>Genetic aspects</subject><subject>Genetic markers</subject><subject>Genotype &amp; phenotype</subject><subject>Genotypes</subject><subject>Health aspects</subject><subject>Health risk assessment</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Hypercholesterolemia</subject><subject>Kuwait</subject><subject>Low density lipoprotein</subject><subject>Male</subject><subject>Mathematical models</subject><subject>Middle Aged</subject><subject>Minority &amp; ethnic groups</subject><subject>Molecular modelling</subject><subject>Oxidation</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population (statistical)</subject><subject>Risk</subject><subject>Risk factors</subject><subject>Smoking</subject><subject>Statistical analysis</subject><subject>Statistical methods</subject><issn>0278-0240</issn><issn>1875-8630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqN0U1v1DAQBmALgehSuHFGkbggQeiMY8fxpdKyfLSiUisE4mi5jr3rksSLnVD13-OwSwucOPngR69n_BLyFOE1IudHFFAc1bKuWCXukQU2gpdNXcF9sgAqmhIogwPyKKUrAKSSyYfkgMqqphz5gnw9HUy0Otm2-OTTtyK4YtzYYnlx_qaICZEKiSCLi9Dd9CFuNz71hQuxWJ28LXQfhvUv_nG61n70mW2nTo8-DI_JA6e7ZJ_sz0Py5f27z6uT8uz8w-lqeVYaVuNYNpo3zkjG24Y5JlBYgygYl1Q3rAVthAEEahtwkAfG1tYM2su8uJQSGlcdkuNd7na67G1r7DBG3alt9L2ONypor_6-GfxGrcMPxUUlWMVzwIt9QAzfJ5tG1ftkbNfpwYYpKZzfmTFk-vwfehWmOOT1VC4B8sfnDu7UWndW-cGF_K6ZQ9WS89wBh3pWr3bKxJBStO52ZAQ19zpHCrXvNfNnf655i38XmcHLHdj4odXX_j_jbDbW6TuNnLI83k8yea_7</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Al-Rashdan, Ibrahim</creator><creator>Al-Serri, Ahmad</creator><creator>Ismael, Fatma G.</creator><creator>al-Bustan, Suzanne A.</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley &amp; Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1260-4632</orcidid></search><sort><creationdate>20170101</creationdate><title>Increased Risk of the APOB rs11279109 Polymorphism for CHD among the Kuwaiti Population</title><author>Al-Rashdan, Ibrahim ; Al-Serri, Ahmad ; Ismael, Fatma G. ; al-Bustan, Suzanne A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-8a58fc945d84f4717ec1174592a84d0ac7c0102e80f02511de640db11599908f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Apolipoprotein B-100 - genetics</topic><topic>Apolipoproteins</topic><topic>Body mass</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Coronary artery disease</topic><topic>Coronary Disease - genetics</topic><topic>Coronary heart disease</topic><topic>Diagnosis</topic><topic>Female</topic><topic>Genetic analysis</topic><topic>Genetic aspects</topic><topic>Genetic markers</topic><topic>Genotype &amp; phenotype</topic><topic>Genotypes</topic><topic>Health aspects</topic><topic>Health risk assessment</topic><topic>Heart diseases</topic><topic>Humans</topic><topic>Hypercholesterolemia</topic><topic>Kuwait</topic><topic>Low density lipoprotein</topic><topic>Male</topic><topic>Mathematical models</topic><topic>Middle Aged</topic><topic>Minority &amp; ethnic groups</topic><topic>Molecular modelling</topic><topic>Oxidation</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Population (statistical)</topic><topic>Risk</topic><topic>Risk factors</topic><topic>Smoking</topic><topic>Statistical analysis</topic><topic>Statistical methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al-Rashdan, Ibrahim</creatorcontrib><creatorcontrib>Al-Serri, Ahmad</creatorcontrib><creatorcontrib>Ismael, Fatma G.</creatorcontrib><creatorcontrib>al-Bustan, Suzanne A.</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Disease markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al-Rashdan, Ibrahim</au><au>Al-Serri, Ahmad</au><au>Ismael, Fatma G.</au><au>al-Bustan, Suzanne A.</au><au>Palla, Roberta</au><au>Roberta Palla</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased Risk of the APOB rs11279109 Polymorphism for CHD among the Kuwaiti Population</atitle><jtitle>Disease markers</jtitle><addtitle>Dis Markers</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>2017</volume><issue>2017</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>0278-0240</issn><eissn>1875-8630</eissn><abstract>Background. Coronary heart disease (CHD) is among the leading causes of death in Kuwait. This case-control study investigated the genetic association of APOB rs11279109 with CHD in Kuwaitis. Methods. The polymorphism was genotyped in 734 Kuwaiti samples by direct amplification. Statistical analysis with genetic modeling was used to assess its association with CHD. Results. A statistically significant association (P&lt;0.001) between the rs11279109 DD genotype (OR: 2.43, CI: 1.34–4.41) with CHD was observed. A codominant genetic model revealed a 2.69 risk increase (CI: 1.57–4.61) for the DD genotype (P=0.009) independent of age, sex, BMI, smoking, hypercholesterolemia, and ethnicity suggesting APOB rs11279109 as an indicator for the increased risk of CHD. Conclusion. The DD genotype may explain molecular mechanisms that underline increased LDL oxidation leading to arthrosclerosis. The findings emphasize the need to identify genetic markers specific to the CHD patient ethnic group in order to improve prognosis and help in early diagnosis and prevention.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>29362515</pmid><doi>10.1155/2017/6963437</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-1260-4632</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0278-0240
ispartof Disease markers, 2017-01, Vol.2017 (2017), p.1-8
issn 0278-0240
1875-8630
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5737435
source Wiley Online Library Open Access
subjects Apolipoprotein B-100 - genetics
Apolipoproteins
Body mass
Cardiovascular disease
Cardiovascular diseases
Coronary artery disease
Coronary Disease - genetics
Coronary heart disease
Diagnosis
Female
Genetic analysis
Genetic aspects
Genetic markers
Genotype & phenotype
Genotypes
Health aspects
Health risk assessment
Heart diseases
Humans
Hypercholesterolemia
Kuwait
Low density lipoprotein
Male
Mathematical models
Middle Aged
Minority & ethnic groups
Molecular modelling
Oxidation
Polymorphism
Polymorphism, Single Nucleotide
Population (statistical)
Risk
Risk factors
Smoking
Statistical analysis
Statistical methods
title Increased Risk of the APOB rs11279109 Polymorphism for CHD among the Kuwaiti Population
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T19%3A13%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Increased%20Risk%20of%20the%20APOB%20rs11279109%20Polymorphism%20for%20CHD%20among%20the%20Kuwaiti%20Population&rft.jtitle=Disease%20markers&rft.au=Al-Rashdan,%20Ibrahim&rft.date=2017-01-01&rft.volume=2017&rft.issue=2017&rft.spage=1&rft.epage=8&rft.pages=1-8&rft.issn=0278-0240&rft.eissn=1875-8630&rft_id=info:doi/10.1155/2017/6963437&rft_dat=%3Cgale_pubme%3EA550015063%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c461t-8a58fc945d84f4717ec1174592a84d0ac7c0102e80f02511de640db11599908f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2010875343&rft_id=info:pmid/29362515&rft_galeid=A550015063&rfr_iscdi=true