Altered Coupling Between Resting-State Cerebral Blood Flow and Functional Connectivity in Schizophrenia

Respective changes in resting-state cerebral blood flow (CBF) and functional connectivity in schizophrenia have been reported. However, their coupling alterations in schizophrenia remain largely unknown. 89 schizophrenia patients and 90 sex- and age-matched healthy controls underwent resting-state f...

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Bibliographic Details
Published in:Schizophrenia bulletin 2017-10, Vol.43 (6), p.1363-1374
Main Authors: Zhu, Jiajia, Zhuo, Chuanjun, Xu, Lixue, Liu, Feng, Qin, Wen, Yu, Chunshui
Format: Article
Language:English
Subjects:
Adult
Cerebral Cortex - diagnostic imaging
Cerebral Cortex - physiopathology
Connectome - methods
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Nerve Net - diagnostic imaging
Nerve Net - physiopathology
Neurovascular Coupling - physiology
Putamen - diagnostic imaging
Putamen - physiopathology
Regular
Schizophrenia - diagnostic imaging
Schizophrenia - physiopathology
Spin Labels
Thalamus - diagnostic imaging
Thalamus - physiopathology
Young Adult
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Summary:Respective changes in resting-state cerebral blood flow (CBF) and functional connectivity in schizophrenia have been reported. However, their coupling alterations in schizophrenia remain largely unknown. 89 schizophrenia patients and 90 sex- and age-matched healthy controls underwent resting-state functional MRI to calculate functional connectivity strength (FCS) and arterial spin labeling imaging to compute CBF. The CBF-FCS coupling of the whole gray matter and the CBF/FCS ratio (the amount of blood supply per unit of connectivity strength) of each voxel were compared between the 2 groups. Whole gray matter CBF-FCS coupling was decreased in schizophrenia patients relative to healthy controls. In schizophrenia patients, the decreased CBF/FCS ratio was predominantly located in cognitive- and emotional-related brain regions, including the dorsolateral prefrontal cortex, insula, hippocampus and thalamus, whereas an increased CBF/FCS ratio was mainly identified in the sensorimotor regions, including the putamen, and sensorimotor, mid-cingulate and visual cortices. These findings suggest that the neurovascular decoupling in the brain may be a possible neuropathological mechanism of schizophrenia.
ISSN:0586-7614
1745-1701
DOI:10.1093/schbul/sbx051