Anatomical and Optical Properties of Atrial Tissue: Search for a Suitable Animal Model

The purpose of this study was to evaluate structural and optical properties of atrial tissue from common animal models and to compare it with human atria. We aimed to do this in a format that will be useful for development of better ablation tools and/or new means for visualizing atrial lesions. Hum...

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Bibliographic Details
Published in:Cardiovascular engineering and technology 2017-12, Vol.8 (4), p.505-514
Main Authors: Muselimyan, Narine, Jishi, Mohammed Al, Asfour, Huda, Swift, Luther, Sarvazyan, Narine A.
Format: Article
Language:English
Subjects:
Ablation
Ablation Techniques - methods
Age Factors
Aged
Animals
Atria
Biomedical Engineering and Bioengineering
Biomedicine
Cardiology
Cattle
Collagen
Collagen - analysis
Dogs
Engineering
Female
Heart Atria - anatomy & histology
Heart Atria - chemistry
Heart Atria - diagnostic imaging
Humans
Lesions
Male
Middle Aged
Muscles
Optical measurement
Optical properties
Organ Culture Techniques
Pigs
Sheep
Species Specificity
Swine
Wall thickness
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Summary:The purpose of this study was to evaluate structural and optical properties of atrial tissue from common animal models and to compare it with human atria. We aimed to do this in a format that will be useful for development of better ablation tools and/or new means for visualizing atrial lesions. Human atrial tissue from clinically relevant age group was compared and contrasted with atrial tissue of large animal models commonly available for research purposes. These included pigs, sheep, dogs and cows. The presented data include area measurements of smooth atrial surface available for ablation and estimates of thickness of collagen and muscle for five different species. We also described methods to quantify presence of collagen and overall thickness of atrial wall. Provided information enables placement of atrial lesions to locations with clinically relevant atrial wall thickness and macroscopic structure ultimately helping investigators to develop better ablation and imaging tools. It also highlights the impact of collagen thickness on optical measurements and lesion visualization.
ISSN:1869-408X
1869-4098
DOI:10.1007/s13239-017-0329-7