Usefulness of plasma matrix metalloproteinase-9 levels in prediction of in-hospital mortality in patients who received emergent percutaneous coronary artery intervention following myocardial infarction

The aim of the present study was to investigate the predictive value of the plasma matrix metalloproteinase-9 (MMP-9) level at admission for in-hospital mortality in patients who received emergency percutaneous coronary intervention (PCI) following AMI. A single blood sample was collected at admissi...

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Published in:Oncotarget 2017-12, Vol.8 (62), p.105809-105818
Main Authors: Zhu, Jia-Jun, Zhao, Qian, Qu, Hui-Juan, Li, Xiao-Mei, Chen, Qing-Jie, Liu, Fen, Chen, Bang-Dang, Yang, Yi-Ning
Format: Article
Language:English
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Research Paper
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Summary:The aim of the present study was to investigate the predictive value of the plasma matrix metalloproteinase-9 (MMP-9) level at admission for in-hospital mortality in patients who received emergency percutaneous coronary intervention (PCI) following AMI. A single blood sample was collected at admission from 155 consecutive AMI patients who underwent emergent PCI. The plasma levels of MMP-9 value (528.9±191.6 ng/ml) were significantly higher in the patients who died (n=24) than in the survivors (385.4±236.0 ng/ml) during 14 days of hospitalization ( =0.005). The age, left ventricle wall motion score index (WMIS), Global Registry of Acute Coronary Events (GRACE) score and B-type natriuretic peptide (BNP) levels and GENSINI score at admission were significantly different between the patients who died and those who survived (
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.22401