Engineered Microenvironments for Maturation of Stem Cell Derived Cardiac Myocytes

Through the use of stem cell-derived cardiac myocytes, tissue-engineered human myocardial constructs are poised for modeling normal and diseased physiology of the heart, as well as discovery of novel drugs and therapeutic targets in a human relevant manner. This review highlights the recent bioengin...

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Bibliographic Details
Published in:Theranostics 2018, Vol.8 (1), p.124-140
Main Authors: Besser, Rachel R, Ishahak, Matthew, Mayo, Vera, Carbonero, Daniel, Claure, Isabella, Agarwal, Ashutosh
Format: Article
Language:English
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Research Paper
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Summary:Through the use of stem cell-derived cardiac myocytes, tissue-engineered human myocardial constructs are poised for modeling normal and diseased physiology of the heart, as well as discovery of novel drugs and therapeutic targets in a human relevant manner. This review highlights the recent bioengineering efforts to recapitulate microenvironmental cues to further the maturation state of newly differentiated cardiac myocytes. These techniques include long-term culture, co-culture, exposure to mechanical stimuli, 3D culture, cell-matrix interactions, and electrical stimulation. Each of these methods has produced various degrees of maturation; however, a standardized measure for cardiomyocyte maturation is not yet widely accepted by the scientific community.
ISSN:1838-7640
1838-7640
DOI:10.7150/thno.19441