Two-photon microscopy imaging of oxidative stress in human living erythrocytes

Red blood cells (RBCs) are known to be the most suitable cells to study oxidative stress, which is implicated in the etiopathology of many human diseases. The goal of the current study was to develop a new effective approach for assessing oxidative stress in human living RBCs using two-photon micros...

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Bibliographic Details
Published in:Biomedical optics express 2017-12, Vol.8 (12), p.5834-5846
Main Authors: Tsakanova, Gohar, Arakelova, Elina, Ayvazyan, Violetta, Ayvazyan, Anna, Tatikyan, Stepan, Aroutiounian, Rouben, Dalyan, Yeva, Haroutiunian, Samvel, Tsakanov, Vasili, Arakelyan, Arsen
Format: Article
Language:English
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Summary:Red blood cells (RBCs) are known to be the most suitable cells to study oxidative stress, which is implicated in the etiopathology of many human diseases. The goal of the current study was to develop a new effective approach for assessing oxidative stress in human living RBCs using two-photon microscopy. To mimic oxidative stress in human living RBCs, an model was generated followed by two-photon microscopy imaging. The results revealed that oxidative stress is clearly visible on the two-photon microscopy images of RBCs under oxidative stress compared to no fluorescence in controls (
ISSN:2156-7085
2156-7085
DOI:10.1364/BOE.8.005834