High Prevalence of Leptotrichia amnionii, Atopobium vaginae, Sneathia sanguinegens, and Factor 1 Microbes and Association of Spontaneous Abortion among Korean Women

Objective. The purpose of this study was to (i) determine the cervical microbial composition in different abortion samples and to (ii) investigate the correlation between spontaneous abortion and cervical microbes in Korean women. Methods. We collected cervical swabs from women who had never undergo...

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Bibliographic Details
Published in:BioMed research international 2017-01, Vol.2017 (2017), p.1-11
Main Authors: Lee, Jae Kwan, Yu, Ye Lee, Kong, Ji Sook, Kwon, Minji, Oh, Hea Young, Kim, Mi Kyung, Arokiyaraj, Selvaraj, Seo, Sang-Soo, Shin, Moon Kyung
Format: Article
Language:English
Subjects:
Abortion
Biomedical research
Correlation analysis
Factor analysis
Gene sequencing
Health aspects
Microbiota (Symbiotic organisms)
Microorganisms
Miscarriage
Prevalence studies (Epidemiology)
Regression analysis
Statistics
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Summary:Objective. The purpose of this study was to (i) determine the cervical microbial composition in different abortion samples and to (ii) investigate the correlation between spontaneous abortion and cervical microbes in Korean women. Methods. We collected cervical swabs from women who had never undergone abortion (N=36), had spontaneous abortion (N=23), and had undergone induced abortion (N=88) and subjected those samples to 16S rRNA pyrosequencing. Further, factor analysis and correlation between cervical microbiota and spontaneous abortion were evaluated by logistic regression analysis. Results. In spontaneous abortion women, 16 S rRNA gene sequences showed significant increases in Atopobium vaginae, Megasphaera spp., Gardnerella vaginalis, Leptotrichia amnionii, and Sneathia sanguinegens compared to women in nonabortion group. In multivariate logistic regression analysis, A. vaginae (OD = 11.27; 95% = 1.57–81), L. amnionii (OD = 11.47; 95% = 1.22–107.94), S. sanguinegens (OD = 6.89; 95% = 1.07–44.33), and factor 1 microbes (OD = 16.4; 95% = 1.88–42.5) were strongly associated with spontaneous abortion. Conclusions. This study showed a high prevalence of L. amnionii, A. vaginae, S. sanguinegens, and factor 1 microbes in spontaneous abortion and association with spontaneous abortion in Korean women.
ISSN:2314-6133
2314-6141
DOI:10.1155/2017/5435089