Exercise Training under Exposure to Low Levels of Fine Particulate Matter: Effects on Heart Oxidative Stress and Extra-to-Intracellular HSP70 Ratio

Fine particulate matter (PM2.5) promotes heart oxidative stress (OS) and evokes anti-inflammatory responses observed by increased intracellular 70 kDa heat shock proteins (iHSP70). Furthermore, PM2.5 increases the levels of these proteins in extracellular fluids (eHSP70), which have proinflammatory...

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Published in:Oxidative medicine and cellular longevity 2017-01, Vol.2017 (2017), p.1-13
Main Authors: Heck, Thiago Gomes, Ludwig, Mirna Stela, Frizzo, Matias Nunes, Goettems-Fiorin, Pauline Brendler, Sulzbacher, Lucas Machado, Basso, Renan Daniel Bueno, Beber, Lílian Corrêa Costa, dos Santos, Analu Bender, Mai, Aline Sfalcin, Rhoden, Cláudia Ramos
Format: Article
Language:English
Subjects:
Air pollution
Cardiovascular disease
Exercise
Fitness training programs
Health sciences
Heart failure
Heat shock proteins
Hirsch index
Inflammation
Oxidative stress
Physiology
Plasma
Proteins
Rodents
Stress response
Workloads
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Summary:Fine particulate matter (PM2.5) promotes heart oxidative stress (OS) and evokes anti-inflammatory responses observed by increased intracellular 70 kDa heat shock proteins (iHSP70). Furthermore, PM2.5 increases the levels of these proteins in extracellular fluids (eHSP70), which have proinflammatory roles. We investigated whether moderate and high intensity training under exposure to low levels of PM2.5 modifies heart OS and the eHSP70 to iHSP70 ratio (H-index), a biomarker of inflammatory status. Male mice (n=32), 30 days old, were divided into six groups for 12 weeks: control (CON), moderate (MIT) and high intensity training (HIT), exposure to 5 μg of PM2.5 daily (PM2.5), and moderate and high intensity training exposed to PM2.5 (MIT + PM2.5 and HIT + PM2.5 groups). The CON and PM2.5 groups remained sedentary. The MIT + PM2.5 group showed higher heart lipid peroxidation levels than the MIT and PM2.5 groups. HIT and HIT + PM2.5 showed higher heart lipid peroxidation levels and lower eHSP70 and H-index levels compared to sedentary animals. No alterations were found in heart antioxidant enzyme activity or iHSP70 levels. Moderate exercise training under exposure to low levels of PM2.5 induces heart OS but does not modify eHSP70 to iHSP70 ratio (H-index). High intensity exercise training promotes anti-inflammatory profile despite exposure to low levels of PM2.5.
ISSN:1942-0900
1942-0994
DOI:10.1155/2017/9067875