Clinical characteristics of hand, foot and mouth disease in Daklak Province, Vietnam and associated factors of severe cases

The Hand, Foot and Mouth Disease (HFMD) outbreaks occurred throughout Daklak province, Vietnam in 2011. This study reviewed all 744 medical records of HFMD patients admitted to Daklak Hospital in 2011 to describe the clinical characteristics of HFMD patients and determined factors associated with se...

Full description

Saved in:
Bibliographic Details
Published in:Virusdisease 2017-12, Vol.28 (4), p.430-433
Main Authors: Van Pham, Hau, Hoang, Tuan N. A., Duong, Hao T., Phan, Lan T., Phan, Uyen T. N., Ho, Nguyen X., Hoang, Cuong Q.
Format: Article
Language:English
Subjects:
Age
Biochemistry
Biomedical and Life Sciences
Blood pressure
Cell Biology
Demographics
Diarrhea
Dyspnea
Epidemiology
Fever
Hand-foot-and-mouth disease
Hospitals
Illnesses
Laboratories
Leukocytes
Leukocytosis
Life Sciences
Medical records
Microbiology
Myoclonus
Patients
Protein Structure
Regression analysis
Seasons
Short Communication
Ulcers
Vomiting
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The Hand, Foot and Mouth Disease (HFMD) outbreaks occurred throughout Daklak province, Vietnam in 2011. This study reviewed all 744 medical records of HFMD patients admitted to Daklak Hospital in 2011 to describe the clinical characteristics of HFMD patients and determined factors associated with severe illness. Among 744 patients, 63 (8.5%) cases were severe. Most (695, 93.4%) of the cases were 3 years old or younger, and 464 (62.4%) were boys. The number of cases peaked between August and November. Most (726, 97.6%) recovered, 17 severe cases (2.3%) were transferred to higher level hospitals, and one death. Symptoms at admission included fever (93.5% had a fever ≥ 38.5 °C), blisters (99.1%), myoclonus (58.5%), and leukocytosis (> 11,300/mm 3 : 38.8%). Viral cultures were performed for 61 of 63 severe cases, of which 26.2% were positive for Enteroviruses. Multivariable analysis found that oral ulcers (Odds Ratio (OR) 3.74; 95% Confidence Interval (CI) 2.13–6.58), myoclonus (OR 44.75; 95% CI 6.04–331.66) and high white blood cell count (OR 1.08; 95% CI 1.01–1.16 per 1000/mm 3 increase) were significantly associated with severe illness. HFMD mainly occurs in children younger than 3 years old and rainy season. Oral ulcers, myoclonus, and leukocytosis should be closely monitored to promptly detect severe cases of HFMD.
ISSN:2347-3584
2347-3517
DOI:10.1007/s13337-017-0402-8