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Short Chain Fatty Acids in the Colon and Peripheral Tissues: A Focus on Butyrate, Colon Cancer, Obesity and Insulin Resistance
Increased dietary fiber consumption has been associated with many beneficial effects, including amelioration of obesity and insulin resistance. These effects may be due to the increased production of short chain fatty acids, including propionate, acetate and butyrate, during fermentation of the diet...
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| Published in: | Nutrients 2017-12, Vol.9 (12), p.1348 |
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| Main Authors: | , |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c502t-6f55673c2df196b5f41ac9d2605f0f431e3060a58a54dae226b04d419a0787813 |
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| container_title | Nutrients |
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| creator | McNabney, Sean M Henagan, Tara M |
| description | Increased dietary fiber consumption has been associated with many beneficial effects, including amelioration of obesity and insulin resistance. These effects may be due to the increased production of short chain fatty acids, including propionate, acetate and butyrate, during fermentation of the dietary fiber in the colon. Indeed, oral and dietary supplementation of butyrate alone has been shown to prevent high fat-diet induced obesity and insulin resistance. This review focuses on sources of short chain fatty acids, with emphasis on sources of butyrate, mechanisms of fiber and butyrate metabolism in the gut and its protective effects on colon cancer and the peripheral effects of butyrate supplementation in peripheral tissues in the prevention and reversal of obesity and insulin resistance. |
| doi_str_mv | 10.3390/nu9121348 |
| format | article |
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| subjects | acetates Acetic acid butyrates Butyrates - metabolism Chains Colon Colon - metabolism Colon cancer Colonic Neoplasms - etiology Colonic Neoplasms - prevention & control Colorectal cancer colorectal neoplasms Dietary fiber Dietary Fiber - pharmacology dietary supplements Fatty acids Fatty Acids, Volatile - metabolism Fermentation Fermentation - drug effects high fat diet Humans Insulin Insulin resistance Insulin Resistance - physiology Metabolism Obesity Obesity - etiology Obesity - prevention & control Propionates - metabolism Propionic acid protective effect Review short chain fatty acids Tissues |
| title | Short Chain Fatty Acids in the Colon and Peripheral Tissues: A Focus on Butyrate, Colon Cancer, Obesity and Insulin Resistance |
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