The Dual Antioxidant/Prooxidant Effect of Eugenol and Its Action in Cancer Development and Treatment

The formation of reactive oxygen species (ROS) during metabolism is a normal process usually compensated for by the antioxidant defense system of an organism. However, ROS can cause oxidative damage and have been proposed to be the main cause of age-related clinical complications and diseases such a...

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Bibliographic Details
Published in:Nutrients 2017-12, Vol.9 (12), p.1367
Main Authors: Bezerra, Daniel Pereira, Militão, Gardenia Carmen Gadelha, de Morais, Mayara Castro, de Sousa, Damião Pergentino
Format: Article
Language:English
Subjects:
antineoplastic activity
antioxidant activity
Antioxidants
Aromatic compounds
Cancer
carcinogenesis
Carcinogens
Complications
Cosmetics
Cytotoxicity
diet
drugs
Eugenol
foods
human health
Metabolism
neoplasms
Oxidative stress
Reactive oxygen species
Reagents
Review
Spices
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Summary:The formation of reactive oxygen species (ROS) during metabolism is a normal process usually compensated for by the antioxidant defense system of an organism. However, ROS can cause oxidative damage and have been proposed to be the main cause of age-related clinical complications and diseases such as cancer. In recent decades, the relationship between diet and cancer has been more studied, especially with foods containing antioxidant compounds. Eugenol is a natural compound widely found in many aromatic plant species, spices and foods and is used in cosmetics and pharmaceutical products. Eugenol has a dual effect on oxidative stress, which can action as an antioxidant or prooxidant agent. In addition, it has anti-carcinogenic, cytotoxic and antitumor properties. Considering the importance of eugenol in the area of food and human health, in this review, we discuss the role of eugenol on redox status and its potential use in the treatment and prevention of cancer.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu9121367