Human embryonic stem cells contribute to embryonic and extraembryonic lineages in mouse embryos upon inhibition of apoptosis

Dear Editor, Recently, interspecies chimera formation has been established in rodents by injection of rat pluripotent stem cells （PSCs） into mouse early embryos, and such a system provides an in vivo assay to test the developmental potential of human PSCs （hPSCs） [1]. In addition, the interspecies c...

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Bibliographic Details
Published in:Cell research 2018-01, Vol.28 (1), p.126-129
Main Authors: Wang, Xuepeng, Li, Tianda, Cui, Tongtong, Yu, Dawei, Liu, Chao, Jiang, Liyuan, Feng, Guihai, Wang, Lei, Fu, Rui, Zhang, Xinxin, Hao, Jie, Wang, Yukai, Wang, Liu, Zhou, Qi, Li, Wei, Hu, Baoyang
Format: Article
Language:English
Subjects:
631/136/2444
631/136/532/2117
631/80/82/23
631/80/86
Animals
Apoptosis
bcl-X Protein - metabolism
Biomedical and Life Sciences
Blastocyst - metabolism
Cell Biology
Chimera - embryology
Chimera - metabolism
Embryo cells
Embryo, Mammalian - cytology
Embryo, Mammalian - metabolism
Embryonic Development
Embryos
Human Embryonic Stem Cells - physiology
Humans
Letter to the Editor
Life Sciences
Mice
Proto-Oncogene Proteins c-bcl-2 - metabolism
Stem cell transplantation
Stem cells
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Summary:Dear Editor, Recently, interspecies chimera formation has been established in rodents by injection of rat pluripotent stem cells （PSCs） into mouse early embryos, and such a system provides an in vivo assay to test the developmental potential of human PSCs （hPSCs） [1]. In addition, the interspecies chimeras formed between hPSCs and large animal embryos would open new avenues to generate human tissues and organs for regenerative medicine [2]. In rodents, embryonic stem cells （ESCs） and epiblast stem cells （EpiSCs） have been derived from inner cell mass （ICM） of the blastocyst and post-implantation epiblast respectively [3, 4].
ISSN:1001-0602
1748-7838
DOI:10.1038/cr.2017.138