The Immunologic Response to Trichophyton Rubrum in Lower Extremity Fungal Infections

Manifestations of infestations, such as tinea pedis, tinea cruris, and tinea corporis, are among the most common human skin diseases seen throughout the world. About 80% of patients presenting with acute dermatophytosis respond well to topical antifungal treatment. However, the remaining 20% of pati...

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Bibliographic Details
Published in:Journal of fungi (Basel) 2015-07, Vol.1 (2), p.130-137
Main Authors: Blutfield, Matthew S, Lohre, Jenna M, Pawich, Derek A, Vlahovic, Tracey C
Format: Article
Language:English
Subjects:
Antigens
Athletes foot
Carbohydrates
Chronic infection
Conflicts of interest
Cytokines
Cytotoxicity
Defense
Dendritic cells
Dermatomycosis
Fungal infections
Fungi
Immune response (cell-mediated)
Immune system
Literature reviews
Patients
Review
Skin
Skin diseases
Tinea corporis
Tinea cruris
Tinea pedis
Trichophyton rubrum
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Summary:Manifestations of infestations, such as tinea pedis, tinea cruris, and tinea corporis, are among the most common human skin diseases seen throughout the world. About 80% of patients presenting with acute dermatophytosis respond well to topical antifungal treatment. However, the remaining 20% of patients progress into a chronic state of dermatophytosis, which is resistant to antifungal treatment. Therefore, it is necessary to have a better understanding and appreciation for the diverse immune responses to Trichophyton as this is critical for the development of therapeutic strategies for those individuals who suffer from a chronic manifestation of ( ) infection. As a result, a comprehensive literature review was conducted to review and discuss previous studies that evaluated the human body's defense to infections and to understand why and how these fungal infections invade the host defense system. Our research revealed that a cell-mediated immune response is critical in defending the body against . However, this organism has mechanisms that enable it to evade the immune system. Therefore, a more successful treatment for chronic infection would involve targeting the mechanisms of that diminish the immune response, while restoring the cell-mediated immune response.
ISSN:2309-608X
2309-608X
DOI:10.3390/jof1020130