Human Ageing Genomic Resources: new and updated databases

Abstract In spite of a growing body of research and data, human ageing remains a poorly understood process. Over 10 years ago we developed the Human Ageing Genomic Resources (HAGR), a collection of databases and tools for studying the biology and genetics of ageing. Here, we present HAGR's main...

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Bibliographic Details
Published in:Nucleic acids research 2018-01, Vol.46 (D1), p.D1083-D1090
Main Authors: Tacutu, Robi, Thornton, Daniel, Johnson, Emily, Budovsky, Arie, Barardo, Diogo, Craig, Thomas, Diana, Eugene, Lehmann, Gilad, Toren, Dmitri, Wang, Jingwei, Fraifeld, Vadim E, de Magalhães, João P
Format: Article
Language:English
Subjects:
Aging - genetics
Animals
Cellular Senescence - genetics
Database Issue
Databases, Genetic
Disease - genetics
Genetic Variation
Genomics
Humans
Longevity - drug effects
Longevity - genetics
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Summary:Abstract In spite of a growing body of research and data, human ageing remains a poorly understood process. Over 10 years ago we developed the Human Ageing Genomic Resources (HAGR), a collection of databases and tools for studying the biology and genetics of ageing. Here, we present HAGR's main functionalities, highlighting new additions and improvements. HAGR consists of six core databases: (i) the GenAge database of ageing-related genes, in turn composed of a dataset of >300 human ageing-related genes and a dataset with >2000 genes associated with ageing or longevity in model organisms; (ii) the AnAge database of animal ageing and longevity, featuring >4000 species; (iii) the GenDR database with >200 genes associated with the life-extending effects of dietary restriction; (iv) the LongevityMap database of human genetic association studies of longevity with >500 entries; (v) the DrugAge database with >400 ageing or longevity-associated drugs or compounds; (vi) the CellAge database with >200 genes associated with cell senescence. All our databases are manually curated by experts and regularly updated to ensure a high quality data. Cross-links across our databases and to external resources help researchers locate and integrate relevant information. HAGR is freely available online (http://genomics.senescence.info/).
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/gkx1042