Protective immune responses of major Vγ2Vδ2 T-cell subset in M. tuberculosis infection

Highlights • HMBPP is required for immune responses/functions of Vγ2Vδ2T cells during infections. • Broad cytokines involve effector functions of Vγ2Vδ2T cells in Mtb infection. • Early responses of Vγ2Vδ2T cells can increase resistance to Mtb infection.

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Bibliographic Details
Published in:Current opinion in immunology 2016-10, Vol.42, p.105-112
Main Author: Chen, Zheng W
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antigens, CD - immunology
Butyrophilins - immunology
Cell Proliferation
Cytotoxicity, Immunologic
Disease Models, Animal
Humans
Immunity, Innate
Immunologic Memory
Interferon-gamma - metabolism
Lung - immunology
Lymphocyte Activation
Mycobacterium tuberculosis - immunology
Primates
Receptors, Antigen, T-Cell, gamma-delta - metabolism
T-Lymphocytes - immunology
Tuberculosis - immunology
Tuberculosis Vaccines - immunology
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Description
Summary:Highlights • HMBPP is required for immune responses/functions of Vγ2Vδ2T cells during infections. • Broad cytokines involve effector functions of Vγ2Vδ2T cells in Mtb infection. • Early responses of Vγ2Vδ2T cells can increase resistance to Mtb infection.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2016.06.005