Longitudinal study of esophageal mucosal damage after esophagectomy and gastric interposition: relationship between reflux-related mucosal injury and Notch signaling

Esophagectomy with gastric interposition could serve as a good human reflux model to study the molecular pathogenesis of esophageal mucosal damage induced by gastroesophageal reflux. This study was to investigate the role of Notch signaling in reflux injury of esophageal mucosa. Patients undergoing...

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Bibliographic Details
Published in:Journal of thoracic disease 2017-12, Vol.9 (12), p.5249-5260
Main Authors: Yuan, Yong, Tong, Tie-Jun, Zeng, Xiao-Xi, Yang, Yu-Shang, Wang, Zhi-Qiang, Wang, Yun-Cang, Gou, Jun-He, Chen, Long-Qi
Format: Article
Language:English
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Summary:Esophagectomy with gastric interposition could serve as a good human reflux model to study the molecular pathogenesis of esophageal mucosal damage induced by gastroesophageal reflux. This study was to investigate the role of Notch signaling in reflux injury of esophageal mucosa. Patients undergoing Ivor-Lewis esophagectomy for early stage esophageal squamous cell carcinoma were included. Follow-ups were scheduled at 6, 18, 36 and 48 months postoperatively, including reflux symptom assessment, endoscopic and histological evaluation of esophageal mucosal damage. The expressions of and its downstream target gene were evaluated by real-time polymerase chain reaction (PCR) and immunohistochemistry (IHC). Forty-four out of 48 patients completed four follow-ups. Injuries of esophageal remnant confirmed by endoscopical and histological examinations were both more often with a longer postoperative period (P
ISSN:2072-1439
2077-6624
DOI:10.21037/jtd.2017.11.16