The prognostic value of abnormally expressed lncRNAs in prostatic carcinoma: A systematic review and meta-analysis

Several long noncoding RNAs (lncRNAs) are abnormally expressed in prostate cancer (PCa), suggesting that they could serve as novel prognostic markers. The current meta-analysis was undertaken to better define the prognostic value of various lncRNAs in PCa. The PubMed, Embase, Medline, and Cochrane L...

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Bibliographic Details
Published in:Medicine (Baltimore) 2017-12, Vol.96 (51), p.e9279-e9279
Main Authors: Wu, Xian-Lan, Zhang, Ji-Wang, Li, Bai-Song, Peng, Shu-Sheng, Yuan, Yong-Qiang
Format: Article
Language:English
Subjects:
Aged
Disease-Free Survival
Gene Expression Regulation, Neoplastic
Humans
Male
Middle Aged
Neoplasm Invasiveness - pathology
Neoplasm Staging
Prognosis
Prostatic Neoplasms - genetics
Prostatic Neoplasms - mortality
Prostatic Neoplasms - pathology
Prostatic Neoplasms - therapy
Risk Assessment
RNA, Long Noncoding - genetics
Survival Analysis
Systematic Review and Meta-Analysis
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Summary:Several long noncoding RNAs (lncRNAs) are abnormally expressed in prostate cancer (PCa), suggesting that they could serve as novel prognostic markers. The current meta-analysis was undertaken to better define the prognostic value of various lncRNAs in PCa. The PubMed, Embase, Medline, and Cochrane Library databases were systematically searched up to February 19, 2017, to retrieve eligible articles. Outcomes analyzed were biochemical recurrence-free survival (BRFS), overall survival (OS), metastasis-free survival (MFS), and prostate cancer-specific survival (PCSS). Pooled hazard ratios (HRs) and 95% confidence intervals (95%CIs) were calculated using fixed-effects or random-effects models. A total of 10 studies, evaluating 11 PCa-related lncRNAs, were included in the meta-analysis. Pooled results indicate that the abnormal expression of candidate lncRNAs in PCa samples predicted poor BRFS (HR: 1.67, 95%CI: 1.37-2.04, P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000009279