Traditional Chinese medicine as an adjunctive therapy to oral montelukast for treating patients with chronic asthma

This study aimed to explore the efficacy and safety of Ping Chuan Ke Li (PCKL) as an adjunctive therapy to oral montelukast compared with placebo plus montelukast for treating patients with chronic asthma (CAS). This randomized controlled trial involved 72 patients with CAS. They were randomly alloc...

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Published in:Medicine (Baltimore) 2017-12, Vol.96 (51), p.e9291-e9291
Main Authors: Wang, Xuehui, Tian, Ziting, Gao, Fengli, Zhang, Xia, Liu, Jianqiu, Li, Zhuying
Format: Article
Language:English
Subjects:
Acetates - therapeutic use
Administration, Oral
Adolescent
Adult
Asthma - diagnosis
Asthma - therapy
China
Clinical Trial/Experimental Study
Double-Blind Method
Drug Therapy, Combination
Drugs, Chinese Herbal - therapeutic use
Female
Follow-Up Studies
Hospitals, University
Humans
Male
Medicine, Chinese Traditional
Middle Aged
Quality of Life
Quinolines - therapeutic use
Respiratory Function Tests
Risk Assessment
Statistics, Nonparametric
Treatment Outcome
Young Adult
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container_issue 51
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creator Wang, Xuehui
Tian, Ziting
Gao, Fengli
Zhang, Xia
Liu, Jianqiu
Li, Zhuying
description This study aimed to explore the efficacy and safety of Ping Chuan Ke Li (PCKL) as an adjunctive therapy to oral montelukast compared with placebo plus montelukast for treating patients with chronic asthma (CAS). This randomized controlled trial involved 72 patients with CAS. They were randomly allocated to an intervention group or a control group, 36 subjects per group. Participants in the intervention group received PCKL and oral montelukast, while those in the control group received placebo and oral montelukast. The primary outcome was lung function, measured by forced expiratory volume in 1 second (FEV1). The secondary outcomes included quality of life, measured by St. George's Respiratory Questionnaire (SGRQ), and adverse events (AEs). Compared to placebo plus montelukast, PCKL and montelukast revealed greater efficacy in lung function, measured by FEV1 (P 
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This randomized controlled trial involved 72 patients with CAS. They were randomly allocated to an intervention group or a control group, 36 subjects per group. Participants in the intervention group received PCKL and oral montelukast, while those in the control group received placebo and oral montelukast. The primary outcome was lung function, measured by forced expiratory volume in 1 second (FEV1). The secondary outcomes included quality of life, measured by St. George's Respiratory Questionnaire (SGRQ), and adverse events (AEs). Compared to placebo plus montelukast, PCKL and montelukast revealed greater efficacy in lung function, measured by FEV1 (P &lt;.05), and quality of life, measured by the SGRQ scale (P &lt;.05). Additionally, no significant differences were found in AEs between the 2 groups. Traditional Chinese medicine PCKL as an adjunctive therapy to oral montelukast alleviated the symptoms of CAS. Future studies with larger sample sizes are still needed to verify the efficacy and safety of PCKL plus montelukast in patients with CAS.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000009291</identifier><identifier>PMID: 29390493</identifier><language>eng</language><publisher>United States: The Authors. Published by Wolters Kluwer Health, Inc. 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Future studies with larger sample sizes are still needed to verify the efficacy and safety of PCKL plus montelukast in patients with CAS.</abstract><cop>United States</cop><pub>The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>29390493</pmid><doi>10.1097/MD.0000000000009291</doi><oa>free_for_read</oa></addata></record>
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subjects Acetates - therapeutic use
Administration, Oral
Adolescent
Adult
Asthma - diagnosis
Asthma - therapy
China
Clinical Trial/Experimental Study
Double-Blind Method
Drug Therapy, Combination
Drugs, Chinese Herbal - therapeutic use
Female
Follow-Up Studies
Hospitals, University
Humans
Male
Medicine, Chinese Traditional
Middle Aged
Quality of Life
Quinolines - therapeutic use
Respiratory Function Tests
Risk Assessment
Statistics, Nonparametric
Treatment Outcome
Young Adult
title Traditional Chinese medicine as an adjunctive therapy to oral montelukast for treating patients with chronic asthma
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